Evidence map›Paper›PMID 32933551›Full record

ArticleJournal of orthopaedic surgery and research2020

Comparing the efficacy of syngeneic iliac and femoral allografts with iliac crest autograft in a rat model of lumbar spinal fusion.

Christina Holmes, Benjamin D Elder, Wataru Ishida, Alexander Perdomo-Pantoja, John Locke, Ethan Cottrill, Sheng-Fu L Lo, Timothy F Witham

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Christina HolmesDepartment of Chemical and Biomedical Engineering, Florida A&M University-Florida State University College of Engineering, Tallahassee, FL, USA. caholmes@eng.famu.fsu.edu.ORCID http://orcid.org/0000-0003-0736-0503
Benjamin D ElderDepartment of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Wataru IshidaDepartment of Neurosurgery, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Alexander Perdomo-PantojaDepartment of Neurosurgery, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
John LockeDepartment of Neurosurgery, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Ethan CottrillDepartment of Neurosurgery, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Sheng-Fu L LoDepartment of Neurosurgery, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Timothy F WithamDepartment of Neurosurgery, The Johns Hopkins University, School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · USFlorida A&M University - Florida State University College of Engineering · USMayo Clinic in Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite widespread use of femoral-sourced allografts in clinical spinal fusion procedures and the increasing interest in using femoral reamer-irrigator-aspirator (RIA) autograft in clinical bone grafting, few studies have examined the efficacy of femoral grafts compared to iliac crest grafts in spinal fusion. The objective of this study was to directly compare the use of autologous iliac crest with syngeneic femoral and iliac allograft bone in the rat model of lumbar spinal fusion.

methodsSingle-level bilateral posterolateral intertransverse process lumbar spinal fusion surgery was performed on Lewis rats divided into three experimental groups: iliac crest autograft, syngeneic iliac crest allograft, and syngeneic femoral allograft bone. Eight weeks postoperatively, fusion was evaluated via microCT analysis, manual palpation, and histology. In vitro analysis of the colony-forming and osteogenic capacity of bone marrow cells derived from rat femurs and hips was also performed to determine whether there was a correlation with the fusion efficacy of these graft sources.

resultsAlthough no differences were observed between groups in CT fusion mass volumes, iliac allografts displayed an increased number of radiographically fused fusion masses and a higher rate of bilateral fusion via manual palpation. Histologically, hip-derived grafts showed better integration with host bone than femur derived ones, likely associated with the higher concentration of osteogenic progenitor cells observed in hip-derived bone marrow.

conclusionsThis study demonstrates the feasibility of using syngeneic allograft bone in place of autograft bone within inbred rat fusion models and highlights the need for further study of femoral-derived grafts in fusion.

Indexed as

AllograftsAutograftsAnimalsBone Marrow CellsBone TransplantationCells, CulturedDisease Models, AnimalFeasibility StudiesFemaleFemurIliumLumbar VertebraeOsteogenesisRats, Inbred LewSpinal FusionStem CellsAllograftAnimal modelAutograftBone marrow cellsSpinal fusion

Identifiers

PMID32933551
PMCPMC7490887
OpenAlexW3084785351

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.