ArticleCardiovascular diabetology2020
Long-term trajectories of BMI predict carotid stiffness and plaque volume in type 2 diabetes older adults: a cohort study.
Article in Cardiovascular diabetology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 34 citations in OpenAlex.
- Association of Composite Metabolic Indices With Incident Carotid Plaque: A Chinese Cohort Study.Journal of the American Heart Association · 2026Article
- Comparison of deep learning reconstruction and iterative reconstruction algorithms for virtual monoenergetic image quality in overweight and obese patients with triple-low scan protocol dual-energy carotid computed tomography angiography.Quantitative imaging in medicine and surgery · 2026Article
- Comprehensive analysis of risk factors associated with carotid plaque in patients with type 2 diabetes mellitus.World journal of diabetes · 2025Article
- Development and validation of a carotid plaque risk prediction model for coal miners.Frontiers in cardiovascular medicine · 2025Article
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- Healthy lifestyles and rapid progression of carotid plaque in population with atherosclerosis: A prospective cohort study in China.Preventive medicine reports · 2024Article
- Associations of trajectories in body roundness index with incident cardiovascular disease: a prospective cohort study in rural China.Frontiers in nutrition · 2024Article
- Non-linear association and benchmark dose of blood pressure on carotid artery intima-media thickening in a general population of southern China.Frontiers in cardiovascular medicine · 2024Article
- Sex-specific medication trajectories in older adults newly diagnosed with diabetes.Exploratory research in clinical and social pharmacy · 2023Article
- Great diversity in the utilization and reporting of latent growth modeling approaches in type 2 diabetes: A literature review.Heliyon · 2022Review
- Prediction of carotid plaque by blood biochemical indices and related factors based on Fisher discriminant analysis.BMC cardiovascular disorders · 2022Article
- The Impact of Dietary Diversity, Lifestyle, and Blood Lipids on Carotid Atherosclerosis: A Cross-Sectional Study.Nutrients · 2022Article
- Impaired sensitivity to thyroid hormones and carotid plaque in patients with coronary heart disease: A RCSCD-TCM study in China.Frontiers in endocrinology · 2022Article
- The risk of carotid plaque instability in patients with metabolic syndrome is higher in women with hypertriglyceridemia.Cardiovascular diabetology · 2021Article
- The Predictive Value of Carotid Ultrasonography With Cardiovascular Risk Factors-A "SPIDER" Promoting Atherosclerosis.Frontiers in cardiovascular medicine · 2021Review
- The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundHigh body mass index (BMI) is a risk factor for type 2 diabetes and cardiovascular disease. However, its relationships with indices of carotid stiffness and plaque volume are unclear. We investigated associations of long-term measurements of BMI with indices of carotid stiffness and atherosclerosis among non-demented diabetes patients from the Israel Diabetes and Cognitive Decline (IDCD) study.
methodsCarotid ultrasound indices [carotid intima media thickness (cIMT), distensibility, elastography and plaque volume] were assessed in N = 471 participants. Mean BMI across all MHS diabetes registry measurements and trajectories of BMI were calculated. BMI was categorized into three trajectory groups representing: a relatively stable normal weight (n = 185, 44%), overweight trajectory (n = 188, 44.8%) and a trajectory of obesity (n = 47, 11.2%). Linear and logistic regressions estimated associations of carotid indices with mean BMI and BMI trajectories.
resultsCompared to the normal weight trajectory, an obesity trajectory was associated with carotid distensibility (β = - 3.078, p = 0.037), cIMT (β = 0.095, p = 0.004), and carotid elastography (β = 0.181, p = 0.004) but not with plaque volume (β = 0.066, p = 0.858). Compared with the normal weight trajectory, an obesity trajectory was associated with increased odds for impaired carotid distensibility (OR = 2.790, p = 0.033), impaired cIMT (OR = 5.277, p = 0.001) and large carotid plaque volume (OR = 8.456, p = 0.013) but not with carotid elastography (OR = 1.956, p = 0.140). Mean BMI was linearly associated with Distensibility (β = - 0.275, p = 0.005) and cIMT (β = 0.005, p = 0.026).
conclusionsLong-term measurements of adiposity are associated with indices of carotid stiffness and plaque volume among older type 2 diabetes adults.
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