Evidence map›Paper›PMID 32933533›Full record

ArticleJournal of nanobiotechnology2020

Hafnium (IV) oxide obtained by atomic layer deposition (ALD) technology promotes early osteogenesis via activation of Runx2-OPN-mir21A axis while inhibits osteoclasts activity.

A Seweryn, M Alicka, A Fal, K Kornicka-Garbowska, K Lawniczak-Jablonska, M Ozga, P Kuzmiuk, M Godlewski, K Marycz

Open access · goldAbstract read
In one paragraph

Article in Journal of nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Periodic Table of Immunomodulatory Elements and Derived Two-Dimensional Biomaterials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Ultrathin ALD Coatings of Zr and V Oxides on Anodic TiOACS applied materials & interfaces · 2025
    Article
  4. Article
  5. Article
  6. Bioactive elements manipulate bone regeneration.Biomaterials translational · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

A SewerynInstitute of Physics, Polish Academy of Sciences, 02668, Warsaw, Poland.
M AlickaDepartment of Experimental Biology, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Norwida 27B, 50-375, Wrocław, Poland.
A FalCardinal Stefan Wyszynski University, Collegium Medicum, 01938, Warsaw, Poland.
K Kornicka-GarbowskaDepartment of Experimental Biology, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Norwida 27B, 50-375, Wrocław, Poland.
K Lawniczak-JablonskaInstitute of Physics, Polish Academy of Sciences, 02668, Warsaw, Poland.
M OzgaInstitute of Physics, Polish Academy of Sciences, 02668, Warsaw, Poland.
P KuzmiukInstitute of Physics, Polish Academy of Sciences, 02668, Warsaw, Poland.
M GodlewskiInstitute of Physics, Polish Academy of Sciences, 02668, Warsaw, Poland.
K MaryczDepartment of Experimental Biology, Faculty of Biology and Animal Science, Wrocław University of Environmental and Life Sciences, Norwida 27B, 50-375, Wrocław, Poland. krzysztof.marycz@upwr.edu.pl.
Polish Academy of Sciences · PLCardinal Stefan Wyszyński University in Warsaw · PLInstitute of Physics · PLInternational Life Sciences Institute India · INWroclaw University of Environmental and Life Sciences · PL

Funding

Narodowe Centrum Nauki 2017/26/M/NZ5/01184
6 · The paper itself

Abstract

backgroundDue to increasing aging of population prevalence of age-related disorders including osteoporosis is rapidly growing. Due to health and economic impact of the disease, there is an urgent need to develop techniques supporting bone metabolism and bone regeneration after fracture. Due to imbalance between bone forming and bone resorbing cells, the healing process of osteoporotic bone is problematic and prolonged. Thus searching for agents able to restore the homeostasis between these cells is strongly desirable.

resultsIn the present study, using ALD technology, we obtained homogeneous, amorphous layer of hafnium (IV) oxide (HfO

conclusionHfO

Indexed as

AnimalsBiocompatible MaterialsBone RegenerationBone ResorptionCell ProliferationCore Binding Factor Alpha 1 SubunitHafniumHomeostasisMacrophagesMiceMicroRNAsOsteoblastsOsteoclastsOsteogenesisOsteoporosisOxidesBiocompatible MaterialsCore Binding Factor Alpha 1 SubunitHafniumMicroRNAsMIRN21 microRNA, humanOxidesRUNX2 protein, humanAtomic layer depositionBiomaterialsHafnium (IV) oxideOsteoblastsOsteoclastsOsteoporosis

Identifiers

PMID32933533
PMCPMC7493872
OpenAlexW3085768249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.