ArticleJournal of translational medicine2020
Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection.
Article in Journal of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 6 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 6 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Frailty and mortality associations in patients with COVID-19: a systematic review and meta-analysis.Internal medicine journal · 2022Pooled it
- Association of frailty with outcomes in individuals with COVID-19: A living review and meta-analysis.Journal of the American Geriatrics Society · 2021Pooled it
- Asthma in patients with coronavirus disease 2019: A systematic review and meta-analysis.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2021Pooled it
- Frailty as a predictor of mortality among patients with COVID-19: a systematic review and meta-analysis.BMC geriatrics · 2021Pooled it
- The Impact of Frailty on COVID-19 Outcomes: A Systematic Review and Meta-analysis of 16 Cohort Studies.The journal of nutrition, health & aging · 2021Pooled it
- The Prognostic Accuracy of National Early Warning Score 2 on Predicting Clinical Deterioration for Patients With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Trial
- Body temperature as a predictor of mortality in COVID-19.Scientific reports · 2023Article
- Anti-inflammatory or anti-SARS-CoV-2 ingredients in Huashi Baidu Decoction and their corresponding targets: Target screening and molecular docking study.Arabian journal of chemistry · 2023Article
- Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio, are they markers of COVID-19 severity or old age and frailty? A comparison of two distinct cohorts.Frontiers in medicine · 2023Article
- A robust COVID-19 mortality prediction calculator based on Lymphocyte count, Urea, C-Reactive Protein, Age and Sex (LUCAS) with chest X-rays.Scientific reports · 2022Article
- SARS-CoV-2-Infection (COVID-19): Clinical Course, Viral Acute Respiratory Distress Syndrome (ARDS) and Cause(s) of Death.Medical sciences (Basel, Switzerland) · 2022Review
- Older Age and Frailty are Associated with Higher Mortality but Lower ICU Admission with COVID-19.Canadian geriatrics journal : CGJ · 2022Article
- Heterogeneity and Risk of Bias in Studies Examining Risk Factors for Severe Illness and Death in COVID-19: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2022Review
- Autoimmunity is a hallmark of post-COVID syndrome.Journal of translational medicine · 2022Article
- The relationship between frailty, nutritional status, co-morbidity, CT-body composition and systemic inflammation in patients with COVID-19.Journal of translational medicine · 2022Article
- Chest Radiograph Scoring Alone or Combined with Other Risk Scores for Predicting Outcomes in COVID-19.Radiology · 2022Observational
- Outcome predictors in COVID-19: An analysis of emergent systemic inflammation indices in Mexican population.Frontiers in medicine · 2022Article
- Can Renal Parameters Predict the Mortality of Hospitalized COVID-19 Patients?Kidney & blood pressure research · 2022Article
- Challenges to Vaccination against SARS-CoV-2 in Patients with Immune-Mediated Diseases.Vaccines · 2021Review
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere COVID-19 infection results in a systemic inflammatory response (SIRS). This SIRS response shares similarities to the changes observed during the peri-operative period that are recognised to be associated with the development of multiple organ failure.
methodsElectronic patient records for patients who were admitted to an urban teaching hospital during the initial 7-week period of the COVID-19 pandemic in Glasgow, U.K. (17th March 2020-1st May 2020) were examined for routine clinical, laboratory and clinical outcome data. Age, sex, BMI and documented evidence of COVID-19 infection at time of discharge or death certification were considered minimal criteria for inclusion.
resultsOf the 224 patients who fulfilled the criteria for inclusion, 52 (23%) had died at 30-days following admission. COVID-19 related respiratory failure (75%) and multiorgan failure (12%) were the commonest causes of death recorded. Age ≥ 70 years (p < 0.001), past medical history of cognitive impairment (p ≤ 0.001), previous delirium (p < 0.001), clinical frailty score > 3 (p < 0.001), hypertension (p < 0.05), heart failure (p < 0.01), national early warning score (NEWS) > 4 (p < 0.01), positive CXR (p < 0.01), and subsequent positive COVID-19 swab (p ≤ 0.001) were associated with 30-day mortality. CRP > 80 mg/L (p < 0.05), albumin < 35 g/L (p < 0.05), peri-operative Glasgow Prognostic Score (poGPS) (p < 0.05), lymphocytes < 1.5 10
conclusionAge ≥ 70 years and severe systemic inflammation as measured by the peri-operative Glasgow Prognostic Score are independently associated with 30-day mortality among patients admitted to hospital with COVID-19 infection.
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Registered trials
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