Evidence map›Paper›PMID 32933157›Full record

ArticleMicroorganisms2020

Regulating Oral Biofilm from Cariogenic State to Non-Cariogenic State via Novel Combination of Bioactive Therapeutic Composite and Gene-Knockout.

Hong Chen, Yingming Yang, Michael D Weir, Quan Dai, Lei Lei, Negar Homayounfar, Thomas W Oates, Kai Yang, Ke Zhang, Tao Hu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Pathogens (Basel, Switzerland) · 2024
    Article
  2. Article
  3. Article
  4. Exopolysaccharides metabolism and cariogenesis ofJournal of oral microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Hong ChenState Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China.
Yingming YangState Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China.
Michael D WeirDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA.
Quan DaiDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA.
Lei LeiState Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China.
Negar HomayounfarDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA.
Thomas W OatesDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA.
Kai YangDepartment of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100069, China.
Ke ZhangDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA.ORCID 0000-0001-7982-5758
Tao HuState Key Laboratory of Oral Diseases, Department of Operative Dentistry and Endodontics, West China School of Stomatology, National Clinical Research Centre for Oral Diseases, Sichuan University, Chengdu 610041, China.
Hockin H K XuDepartment of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School, Baltimore, MD 21201, USA.
University of Maryland, Baltimore · USSichuan University · CNCapital Medical University · CN

Funding

a bridge grant from the University of Maryland School of Dentistry -Applied Basic Research Program of Sichuan Province 2018JY0580a seed grant from the University of Maryland Baltimore -Beijing Hospitals Authority Ascent Plan DFL20191501Capital's Funds for Health Improvement and Research CFH2020-2-2142National Natural Science Foundation of China 81771068
6 · The paper itself

Abstract

The objectives were to investigate a novel combination of gene-knockout with antimicrobial dimethylaminohexadecyl methacrylate (DMAHDM) composite in regulating oral biofilm from a cariogenic state toward a non-cariogenic state. A tri-species biofilm model included cariogenic

Indexed as

bioactive compositebiofilm–material interactionsdental cariesmulti-species biofilmregulating biofilm compositionS. mutansrnc gene-knockout

Identifiers

PMID32933157
PMCPMC7564907
OpenAlexW3085536640

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.