Evidence map›Paper›PMID 32933042›Full record

ArticleBiomolecules2020

Determining the Molecular Background of Endometrial Receptivity in Adenomyosis.

Erika Prašnikar, Tanja Kunej, Jure Knez, Katja Repnik, Uroš Potočnik, Borut Kovačič

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Erika PrašnikarDepartment of Reproductive Medicine and Gynaecological Endocrinology, University Medical Centre Maribor, 2000 Maribor, Slovenia.
Tanja KunejDepartment of Animal Science, Biotechnical Faculty, University of Ljubljana, 1230 Domžale, Slovenia.ORCID 0000-0002-0465-1762
Jure KnezDepartment of Gynaecologic and Breast Oncology, University Medical Centre Maribor, 2000 Maribor, Slovenia.ORCID 0000-0003-3543-5920
Katja RepnikCentre for Human Molecular Genetics and Pharmacogenomics, Medical faculty, University of Maribor, 2000 Maribor, Slovenia.
Uroš PotočnikCentre for Human Molecular Genetics and Pharmacogenomics, Medical faculty, University of Maribor, 2000 Maribor, Slovenia.ORCID 0000-0003-1624-9428
Borut KovačičDepartment of Reproductive Medicine and Gynaecological Endocrinology, University Medical Centre Maribor, 2000 Maribor, Slovenia.
University Clinical Centre Maribor · SIUniversity of Maribor · SIUniversity of Ljubljana · SI

Funding

Javna Agencija za Raziskovalno Dejavnost RS P3-0327Javna Agencija za Raziskovalno Dejavnost RS P4-0220
6 · The paper itself

Abstract

backgroundAdenomyosis is a gynaecological condition with limited evidence of negative impact to endometrial receptivity. It is commonly associated with endometriosis, which has been shown to alter endometrial expression patterns. Therefore, the candidate genes identified in endometriosis could serve as a source to study endometrial function in adenomyosis.

methodsTranscripts/proteins associated with endometrial receptivity in women with adenomyosis or endometriosis and healthy women were obtained from publications and their nomenclature was adopted according to the HUGO Gene Nomenclature Committee (HGNC). Retrieved genes were analysed for enriched pathways using Cytoscape/Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Reactome tools to prioritise candidates for endometrial receptivity. These were used for validation on women with (

resultsFunctional enrichment analysis of 173, 42 and 151 genes associated with endometriosis, adenomyosis and healthy women, respectively, revealed signalling by interleukins and interleukin-4 and interleukin-13 signalling pathways, from which annotated

conclusionThis is the first integrative study providing putative candidate genes and pathways characterising endometrial receptivity in women with adenomyosis in comparison to healthy women and women with endometriosis.

Indexed as

Gene Expression RegulationAdenomyosisAdultCase-Control StudiesEndometriosisEndometriumFemaleGene Expression ProfilingGene Regulatory NetworksHumansInfertility, FemaleInterleukin-10Interleukin-13Interleukin-4Interleukin-6Leukemia Inhibitory FactorFOS protein, humanIL10 protein, humanIL13 protein, humanIL4 protein, humanIL6 protein, humanInterleukin-10Interleukin-13Interleukin-4Interleukin-6JunB protein, humanLeukemia Inhibitory FactorLIF protein, humanProto-Oncogene Proteins c-fosSOCS3 protein, humanSuppressor of Cytokine Signaling 3 ProteinTranscription Factorsadenomyosiscandidate genesendometrial receptivityendometriosisgene expressiongene set enrichment analysis (GSEA)multi-omicsprotein–protein interaction network (PPIN)

Identifiers

PMID32933042
PMCPMC7563201
OpenAlexW3085255612

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.