Evidence map›Paper›PMID 32933030›Full record

ArticlePharmaceutics2020

Polypeptide Self-Assembled Nanoparticles as Delivery Systems for Polymyxins B and E.

Dmitrii Iudin, Natalia Zashikhina, Elena Demyanova, Viktor Korzhikov-Vlakh, Elena Shcherbakova, Roman Boroznjak, Irina Tarasenko, Natalya Zakharova, Antonina Lavrentieva, Yury Skorik and 1 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  8. Succinyl Chitosan-Colistin Conjugates as Promising Drug Delivery Systems.International journal of molecular sciences · 2022
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  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Dmitrii IudinInstitute of Macromolecular Compounds, Russian Academy of Sciences, 199004 St. Petersburg, Russia.
Natalia ZashikhinaInstitute of Macromolecular Compounds, Russian Academy of Sciences, 199004 St. Petersburg, Russia.ORCID 0000-0002-3039-1327
Elena DemyanovaState Research Institute of Highly Pure Biopreparations, Federal Medical-Biological Agency, 197110 St. Petersburg, Russia.
Viktor Korzhikov-VlakhSaint-Petersburg State University, Institute of Chemistry, 198584 St. Petersburg, Russia.ORCID 0000-0002-3509-3978
Elena ShcherbakovaState Research Institute of Highly Pure Biopreparations, Federal Medical-Biological Agency, 197110 St. Petersburg, Russia.
Roman BoroznjakDepartment of Materials and Environmental Technology, Tallinn University of Technology, 19086 Tallinn, Estonia.
Irina TarasenkoInstitute of Macromolecular Compounds, Russian Academy of Sciences, 199004 St. Petersburg, Russia.
Natalya ZakharovaInstitute of Macromolecular Compounds, Russian Academy of Sciences, 199004 St. Petersburg, Russia.
Antonina LavrentievaInstitute of Technical Chemistry, Gottfried-Wilhelm-Leibniz University of Hannover, 30167 Hannover, Germany.
Yury SkorikInstitute of Macromolecular Compounds, Russian Academy of Sciences, 199004 St. Petersburg, Russia.ORCID 0000-0002-9731-6399
Evgenia Korzhikova-VlakhInstitute of Macromolecular Compounds, Russian Academy of Sciences, 199004 St. Petersburg, Russia.ORCID 0000-0002-2530-7709
Institute of Macromolecular Compounds · RUState Research Institute of Highly Pure Biopreparations · RUSt Petersburg University · RULeibniz University Hannover · DETallinn University of Technology · EE

Funding

Russian Science Foundation 19-73-20157
6 · The paper itself

Abstract

Polymyxins are peptide antibiotics that are highly efficient against many multidrug resistant pathogens. However, the poor stability of polymyxins in the bloodstream requires the administration of high drug doses that, in turn, can lead to polymyxin toxicity. Consequently, different delivery systems have been considered for polymyxins to overcome these obstacles. In this work, we report the development of polymyxin delivery systems based on nanoparticles obtained from the self-assembly of amphiphilic random poly(l-glutamic acid-

Indexed as

drug delivery systemsminimal inhibitory concentrationpeptide antibioticspolymyxin loading and releasepolymyxinspolypeptide nanoparticles

Identifiers

PMID32933030
PMCPMC7558620
OpenAlexW3086949588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.