Evidence map›Paper›PMID 32933008›Full record

ArticleInternational journal of molecular sciences2020

RETRACTED: Ameliorative Properties of Boronic Compounds in In Vitro and In Vivo Models of Alzheimer's Disease.

Panchanan Maiti, Jayeeta Manna, Zoe N Burch, Denise B Flaherty, Joseph D Larkin, Gary L Dunbar

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Stimuli-Responsive Boron-Based Materials in Drug Delivery.International journal of molecular sciences · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. Interactions of a boron-containing levodopa derivative on DJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Panchanan MaitiField Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA.ORCID 0000-0003-3213-8015
Jayeeta MannaField Neurosciences Institute, Ascension St. Mary, Saginaw, MI 48604, USA.
Zoe N BurchDepartment of Biology, Eckerd College, St. Petersburg, FL 33711, USA.
Denise B FlahertyDepartment of Biology, Eckerd College, St. Petersburg, FL 33711, USA.
Joseph D LarkinDepartment of Chemistry, Eckerd College, St. Petersburg, FL 33711, USA.
Gary L DunbarField Neurosciences Institute Laboratory for Restorative Neurology, Central Michigan University, Mt. Pleasant, MI 48859, USA.
Eckerd College · USCentral Michigan University · USField Neurosciences Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by amyloid (Aβ) aggregation, hyperphosphorylated tau, neuroinflammation, and severe memory deficits. Reports that certain boronic compounds can reduce amyloid accumulation and neuroinflammation prompted us to compare trans-2-phenyl-vinyl-boronic-acid-MIDA-ester (TPVA) and trans-beta-styryl-boronic-acid (TBSA) as treatments of deficits in in vitro and in vivo models of AD. We hypothesized that these compounds would reduce neuropathological deficits in cell-culture and animal models of AD. Using a dot-blot assay and cultured N

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsBoronic AcidsCaenorhabditis elegansCell Line, TumorDisease Models, AnimalFemaleHippocampusMaleMemory DisordersMiceMice, TransgenicNeuroprotective AgentsPlaque, AmyloidAmyloid beta-PeptidesAmyloid beta-Protein PrecursorBoronic AcidsNeuroprotective Agents(S)-tert-butanesulfinamideSulfonium CompoundsAlzheimer’s diseaseamyloid beta proteinamyloid plaqueboron compoundC. elegansneurodegenerationneuroinflammation

Identifiers

PMID32933008
PMCPMC7555802
OpenAlexW3086592282

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.