Evidence map›Paper›PMID 32932898›Full record

Trial reportInternational journal of environmental research and public health2020

Evaluation of Salivary Matrix Metalloproteinase (MMP-8) in Periodontal Patients Undergoing Non-Surgical Periodontal Therapy and Mouthwash Based on Ozonated Olive Oil: A Randomized Clinical Trial.

Gianna Maria Nardi, Francesca Cesarano, Giulio Papa, Lorella Chiavistelli, Roman Ardan, Maciej Jedlinski, Marta Mazur, Roberta Grassi, Felice Roberto Grassi

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07402694 (Oral Health Outcomes With Amphion Mouthwash as an Adjunct to Non-Surgical Periodontal Therapy), which is not on this map. Cited by 23 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07402694 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Oral Health Outcomes With Amphion Mouthwash as an Adjunct to Non-Surgical Periodontal Therapy

TypeinterventionalSponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2026 to 2027Enrolled60ConditionsPeriodontitis, MouthwashArmsAmphion® Mouthwash, Placebo Mouthwash
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Trial
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  12. Article
  13. Importance of Metalloproteinase 8 (MMP-8) in the Diagnosis of Periodontitis.International journal of molecular sciences · 2024
    Review
  14. Article
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gianna Maria NardiDepartment of Dental and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Francesca CesaranoDepartment of Dental and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Giulio PapaDepartment of Dental and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Lorella ChiavistelliDepartment of Dental and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Roman ArdanChair of Econometrics, Department of Economic Sciences, Koszalin University of Technology, 75-343 Koszalin, Poland.ORCID 0000-0003-0439-4863
Maciej JedlinskiDepartment of Interdisciplinary Dentistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.ORCID 0000-0003-3446-6119
Marta MazurDepartment of Dental and Maxillofacial Sciences, Sapienza University of Rome, 00161 Rome, Italy.
Roberta GrassiDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Felice Roberto GrassiDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, Aldo Moro University of Bari, 70122 Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Matrix Metalloproteinase 8MouthwashesOlive OilPeriodontal IndexFollow-Up StudiesHumansRoot PlaningMatrix Metalloproteinase 8MouthwashesOlive Oilolive oilozonated oilozoneperiodontitisRCTsalivary metalloproteinase

Identifiers

PMID32932898
PMCPMC7558934

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.