Evidence map›Paper›PMID 32932892›Full record

ReviewBiomolecules2020

Dynamic mRNP Remodeling in Response to Internal and External Stimuli.

Kathi Zarnack, Sureshkumar Balasubramanian, Michael P Gantier, Vladislav Kunetsky, Michael Kracht, M Lienhard Schmitz, Katja Sträßer

Open access · goldAbstract readReview
In one paragraph

Review in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. The RNA Revolution in the Central Molecular Biology Dogma Evolution.International journal of molecular sciences · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Translation ofFrontiers in molecular biosciences · 2023
    Review
  10. Review
  11. Substrates of the MAPK Slt2: Shaping Yeast Cell Integrity.Journal of fungi (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Article
  14. Neurodegeneration and axonal mRNA transportation.American journal of neurodegenerative disease · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Kathi ZarnackBuchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, 60438 Frankfurt a.M., Germany.ORCID 0000-0003-3527-3378
Sureshkumar BalasubramanianSchool of Biological Sciences, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-1057-2606
Michael P GantierCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.ORCID 0000-0003-3740-698X
Vladislav KunetskyInstitute of Biochemistry, FB08, Justus Liebig University, 35392 Giessen, Germany.
Michael KrachtRudolf Buchheim Institute of Pharmacology, FB11, Justus Liebig University, 35392 Giessen, Germany.ORCID 0000-0002-8501-043X
M Lienhard SchmitzInstitute of Biochemistry, FB11, Justus Liebig University, 35392 Giessen, Germany.ORCID 0000-0002-6984-7192
Katja SträßerInstitute of Biochemistry, FB08, Justus Liebig University, 35392 Giessen, Germany.ORCID 0000-0003-3533-5516
Justus-Liebig-Universität Gießen · DEGoethe University Frankfurt · DEHudson Institute of Medical Research · AUMonash University · AU

Funding

Australian National Health and Medical Research Council project 1124485Australian Research Council Discovery Project DP190101479Deutsche Forschungsgemeinschaft EXC 2026: CardioPulmonary Institute (CPI), project 390649896Deutsche Forschungsgemeinschaft GRK2573/1Deutsche Forschungsgemeinschaft GRK 2573, project 416910386Deutsche Forschungsgemeinschaft KR1143/9-2Deutsche Forschungsgemeinschaft RTG2355/1Deutsche Forschungsgemeinschaft SCHM 1417/8-3, project 162103480Deutsche Forschungsgemeinschaft SFB1021, project 197785619Deutsche Forschungsgemeinschaft SFB1213, project 268555672Deutsche Forschungsgemeinschaft SFB902 B13Deutsche Forschungsgemeinschaft SPP1935Deutsche Forschungsgemeinschaft STR697/3-1Deutsche Forschungsgemeinschaft TRR267 A01Deutsche Forschungsgemeinschaft TRR81/2, Project 183582903European Research Council 62300836Max-Planck-Gesellschaft IMPRS programUniklinikum Giessen und Marburg DZL/UGMLC program
6 · The paper itself

Abstract

Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli. However, how signaling pathways regulate the assembly of RBPs with mRNAs remains largely unknown. Here, we summarize observations showing that the formation and composition of messenger ribonucleoprotein particles (mRNPs) is dynamically remodeled in space and time by specific signaling cascades and the resulting post-translational modifications. The integration of signaling events with gene expression is key to the rapid adaptation of cells to environmental changes and stress. Only a combined approach analyzing the signal transduction pathways and the changes in post-transcriptional gene expression they cause will unravel the mechanisms coordinating these important cellular processes.

Indexed as

Protein BiosynthesisProtein Processing, Post-TranslationalActive Transport, Cell NucleusAnimalsArabidopsisHumansMethylationMicroRNAsMitogen-Activated Protein KinasesPhosphorylationRibonucleoproteinsRNA, MessengerRNA SplicingSaccharomyces cerevisiaeSignal TransductionSumoylationmessenger ribonucleoproteinMicroRNAsMitogen-Activated Protein KinasesRibonucleoproteinsRNA, Messengerextracellular stimuliintracellular stimulimessenger ribonucleoprotein particles (mRNPs)post-transcriptional gene regulationRNA-binding proteins (RBPs)signal transductionstress

Identifiers

PMID32932892
PMCPMC7565591
OpenAlexW3084753375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.