Evidence map›Paper›PMID 32932702›Full record

ArticleMolecules (Basel, Switzerland)2020

Novel Acetylcholinesterase Inhibitors Based on Uracil Moiety for Possible Treatment of Alzheimer Disease.

Vyacheslav E Semenov, Irina V Zueva, Marat A Mukhamedyarov, Sofya V Lushchekina, Elena O Petukhova, Lilya M Gubaidullina, Evgeniya S Krylova, Lilya F Saifina, Oksana A Lenina, Konstantin A Petrov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Potential of Vitamin B6 Dioxime Analogues to Act as Cholinesterase Ligands.International journal of molecular sciences · 2022
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Vyacheslav E SemenovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str. 8, 420088 Kazan, Russia.ORCID 0000-0001-8350-2433
Irina V ZuevaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str. 8, 420088 Kazan, Russia.
Marat A MukhamedyarovInstitute of Neuroscience, Kazan State Medical University, 420012 Kazan, Russia.
Sofya V LushchekinaEmanuel Institute of Biochemical Physics, Kosygina st. 4, 119334 Moscow, Russia.ORCID 0000-0002-6922-020X
Elena O PetukhovaInstitute of Neuroscience, Kazan State Medical University, 420012 Kazan, Russia.ORCID 0000-0002-9100-815X
Lilya M GubaidullinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str. 8, 420088 Kazan, Russia.
Evgeniya S KrylovaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str. 8, 420088 Kazan, Russia.
Lilya F SaifinaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str. 8, 420088 Kazan, Russia.
Oksana A LeninaArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str. 8, 420088 Kazan, Russia.
Konstantin A PetrovArbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS, Arbuzov str. 8, 420088 Kazan, Russia.
A.E. Arbuzov Institute of Organic and Physical Chemistry · RUKazan State Medical University · RUInstitute of Biochemical Physics NM Emanuel · RUKazan Federal University · RU

Funding

Ministry of Education and Science of the Russian Federation АААА-А18-118040390114-8Russian Foundation for Basic Research 19-03-00043Russian Science Support Foundation 19-15-00344
6 · The paper itself

Abstract

In this study, novel derivatives based on 6-methyluracil and condensed uracil were synthesized, namely, 2,4-quinazoline-2,4-dione with ω-(

Indexed as

AcetylcholinesteraseAlzheimer DiseaseAmmonium CompoundsAnimalsAnionsBehavior, AnimalBinding SitesBlood-Brain BarrierButyrylcholinesteraseCatalytic DomainCholinesterase InhibitorsDisease Models, AnimalDrug DesignDrug Evaluation, PreclinicalHumansInhibitory Concentration 506-methyluracilAcetylcholinesteraseAmmonium CompoundsAnionsButyrylcholinesteraseCholinesterase InhibitorsScopolamineUracil6-methyluracilacetylcholinesteraseAlzheimer diseaseinhibitorsperipheral anionic site

Identifiers

PMID32932702
PMCPMC7571187
OpenAlexW3086499913

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.