ArticleInternational journal of molecular sciences2020
Aldehyde Dehydrogenase 2 Ameliorates Chronic Alcohol Consumption-Induced Atrial Fibrillation through Detoxification of 4-HNE.
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Diabetes and ALDH2 Gene Polymorphism on Post-Ablation Atrial Fibrillation Recurrence.JACC. Asia · 2026Article
- Influence of e-cigarettes and their constituents on cardiac rhythm and arrhythmias.American journal of physiology. Heart and circulatory physiology · 2026Review
- AldehydeFrontiers in medicine · 2026Article
- Correlation BetweenCardiovascular therapeutics · 2026Article
- Alda-1 attenuation of binge alcohol-caused atrial arrhythmias through a novel mechanism of suppressed c-Jun N-terminal Kinase-2 activity.Journal of molecular and cellular cardiology · 2024Article
- Impaired Osteogenesis in Human Induced Pluripotent Stem Cells with Acetaldehyde Dehydrogenase 2 Mutations.International journal of stem cells · 2024Article
- Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS.Cellular & molecular immunology · 2024Article
- Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial Fibrillation Susceptibility: Unraveling the Connection.International journal of molecular sciences · 2024Article
- A common East-Asian ALDH2 mutation causes metabolic disorders and the therapeutic effect of ALDH2 activators.Nature communications · 2023Article
- The role of aldehyde dehydrogenase 2 in cardiovascular disease.Nature reviews. Cardiology · 2023Review
- Alcohol and Cardiac Arrythmias: A Review of the Current Data.Reviews in cardiovascular medicine · 2023Review
- The potential effects of HECTD4 variants on fasting glucose and triglyceride levels in relation to prevalence of type 2 diabetes based on alcohol intake.Archives of toxicology · 2022Article
- Review
- Activation of aldehyde dehydrogenase 2 protects ethanol-induced osteonecrosis of the femoral head in rat model.Cell proliferation · 2022Article
- Aldehydes, Aldehyde Metabolism, and the ALDH2 Consortium.Biomolecules · 2022Article
- Lipidomic changes of cerebral cortex in aldehyde dehydrogenase-2 knock-in heterozygote mice after chronic alcohol exposure.Frontiers in molecular neuroscience · 2022Article
- Association of acetaldehyde dehydrogenase 2 rs671 polymorphism with the occurrence and progression of atrial fibrillation.Frontiers in cardiovascular medicine · 2022Article
- Variant Aldehyde Dehydrogenase 2 (Biomolecules · 2021Article
- Association between the APOE gene polymorphism and lipid profile and the risk of atrial fibrillation.Lipids in health and disease · 2021Article
- ALDH2 deficiency induces atrial fibrillation through dysregulated cardiac sodium channel and mitochondrial bioenergetics: A multi-omics analysis.Biochimica et biophysica acta. Molecular basis of disease · 2021Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Aldehyde dehydrogenase 2 (ALDH2) is an enzyme that detoxifies reactive oxygen species (ROS)-generated aldehyde adducts such as 4-hydroxy-trans-2-nonenal (4-HNE). Previous meta-analyses have shown an increase in the risk of atrial fibrillation (AF) in patients with chronic alcohol consumption.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.