Evidence map›Paper›PMID 32932411›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2020

Home- and Clinic-Based Pediatric HIV Index Case Testing in Kenya: Uptake, HIV Prevalence, Linkage to Care, and Missed Opportunities.

Cyrus Mugo, Jiayu Wang, Emily R Begnel, Irene N Njuguna, Elizabeth Maleche-Obimbo, Irene Inwani, Jennifer A Slyker, Grace John-Stewart, Dalton C Wamalwa, Anjuli D Wagner

Open access · greenAbstract read
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Index Case HIV Testing Uptake and its Associated Factors at Oromia, Ethiopia.Journal of the International Association of Providers of AIDS Care
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Cyrus MugoDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Jiayu WangDepartment of Global Health, University of Washington, Seattle, WA.
Emily R BegnelDepartment of Global Health, University of Washington, Seattle, WA.
Irene N NjugunaDepartment of Research and Programs, Kenyatta National Hospital, Nairobi, Kenya.
Elizabeth Maleche-ObimboDepartment of Pediatrics, University of Nairobi, Nairobi, Kenya.
Irene InwaniDepartment of Pediatrics, Kenyatta National Hospital, Nairobi, Kenya; and.
Jennifer A SlykerDepartment of Global Health, University of Washington, Seattle, WA.
Grace John-StewartDepartments of Pediatrics.
Dalton C WamalwaDepartment of Pediatrics, University of Nairobi, Nairobi, Kenya.
Anjuli D WagnerDepartment of Global Health, University of Washington, Seattle, WA.
University of Washington · USKenyatta National Hospital · KEUniversity of Nairobi · KE

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI CONNIE L CELUM · 1988 to 2026
$104.9M
Urgent Versus Post-Stabilization ART in HIV+ Children with Severe Co-infectionsR01HD023412 · NICHD · UNIVERSITY OF WASHINGTON · PI Grace C. John-Stewart, DALTON CHEKOKO WAMALWA · 1987 to 2026
$12.2M
Promoting Diversity, Equity, and Inclusivity in Research Training to Optimize HIV Prevention and TreatmentD43TW009580 · FIC · UNIVERSITY OF WASHINGTON · PI CAREY FARQUHAR, John Kinuthia · 2013 to 2026
$4.8M
Women and HIV: Translation of Research into Practice-WLHIV Post-Graduate Research FellowshipD43TW009783 · FIC · UNIVERSITY OF WASHINGTON · PI Elizabeth Anne BUKUSI, CAREY FARQUHAR · 2015 to 2026
$4.1M
Health-Professional Education Partnership Initiative (HEPI) - KenyaR25TW011212 · FIC · UNIVERSITY OF NAIROBI · PI NDUATI, RUTH WANJIRU, WAMALWA, DALTON CHEKOKO · 2018 to 2022
$3.2M
Pediatric HIV-1 in Africa: Pathogenesis and ManagementK24HD054314 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2006 to 2016
$1.2M
Testing implementation strategies to improve delivery of PrEP for pregnant and postpartum women in KenyaK01MH121124 · NIMH · UNIVERSITY OF WASHINGTON · PI WAGNER, ANJULI DAWN · 2019 to 2023
$835k
Vertical CMV transmission in the setting of maternal HIV-1 infection in KenyaK01AI087369 · NIAID · UNIVERSITY OF WASHINGTON · PI SLYKER, JENNIFER ANN · 2010 to 2014
$616k
Hiv-1 Counseling and Testing for Children at Home (CATCH)R21HD079637 · NICHD · UNIVERSITY OF WASHINGTON · PI JOHN-STEWART, GRACE C. · 2014 to 2015
$373k
Systems analysis and improvement approach to improve pediatric HIV testing and linkage to careF32HD088204 · NICHD · UNIVERSITY OF WASHINGTON · PI WAGNER, ANJULI DAWN · 2016 to 2019
$168k
Optimizing Mechanisms for Identifying Older Children with Undiagnosed HIV-1F31MH099988 · NIMH · UNIVERSITY OF WASHINGTON · PI WAGNER, ANJULI DAWN · 2012 to 2015
$120k
FIC NIH HHS D43 TW009580FIC NIH HHS D43 TW009783FIC NIH HHS R25 TW011212NIAID NIH HHS K01 AI087369NIAID NIH HHS P30 AI027757NICHD NIH HHS F32 HD088204NICHD NIH HHS K24 HD054314NICHD NIH HHS R01 HD023412NICHD NIH HHS R21 HD079637NIMH NIH HHS F31 MH099988NIMH NIH HHS K01 MH121124
6 · The paper itself

Abstract

introductionGaps in HIV testing of children persist, particularly among older children born before the expansion of the prevention of mother-to-child transmission of HIV programs.

methodsThe Counseling and Testing for Children at Home study evaluated an index-case pediatric HIV testing approach. Caregivers receiving HIV care at 7 health facilities in Kenya (index cases), who had children of unknown HIV status aged 0-12 years, were offered the choice of clinic-based testing (CBT) or home-based testing (HBT). Testing uptake and HIV prevalence were compared between groups choosing HBT and CBT; linkage to care, missed opportunities, and predictors of HIV-positive diagnosis were identified.

resultsAmong 493 caregivers, 70% completed HIV testing for ≥1 child. Most caregivers who tested children chose CBT (266/347, 77%), with 103 (30%) agreeing to same-day testing of an untested accompanying child. Overall HIV prevalence among 521 tested children was 5.8% (CBT 6.8% vs HBT 2.4%; P = 0.07). Within 1 month of diagnosis, 88% of 30 HIV-positive children had linked to care, and 54% had started antiretroviral treatment. For 851 children eligible for testing, the most common reason for having an unknown HIV status was that the child's mother was not tested for HIV or had tested HIV negative during pregnancy (82%).

conclusionTesting uptake and HIV prevalence were moderate with nonsignificant differences between HBT and CBT. Standardized offer to test children accompanying caregivers is feasible to scale-up with little additional investment. Linkage to care for HIV-positive children was suboptimal. Lack of peripartum maternal testing contributed to gaps in pediatric testing.

Indexed as

Continuity of Patient CareHome Care ServicesChildChild, PreschoolFemaleHIV InfectionsHumansInfantInfant, NewbornKenyaMalePatient Acceptance of Health CarePrevalence

Identifiers

PMID32932411
PMCPMC9383697
OpenAlexW3087004641

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.