ArticleArchives of oral biology2020
Equivalence of human and bovine dentin matrix molecules for dental pulp regeneration: proteomic analysis and biological function.
Article in Archives of oral biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Proteomic signatures of equine dental tooth tissues in ageing and disease.Equine veterinary journal · 2026Article
- Strategies to Microengineer Vascularized, Mineralized, and Immunomodulatory Niches for Dental Regeneration.Journal of endodontics · 2026Article
- Biological, antimicrobial, and apical tissue dissolution effects of ambroxol hydrochloride as an irrigant for regenerative endodontics: an in vitro study.BMC oral health · 2026Article
- Comparative evaluation of 3D culture strategies for pulp-dentin models.BMC oral health · 2026Article
- Effects triggered by tumor necrosis factor-α in immortalized murine dental pulp and pre-osteoblastic cells.Brazilian oral research · 2025Article
- Comparison of the osteogenic effects of demineralized dentin matrix and acellular dentin matrix.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024Article
- 3D-printed microgels supplemented with dentin matrix molecules as a novel biomaterial for direct pulp capping.Clinical oral investigations · 2023Article
- Treated Dentin Matrix in Tissue Regeneration: Recent Advances.Pharmaceutics · 2022Review
- In-vitro models of biocompatibility testing for restorative dental materials: From 2D cultures to organs on-a-chip.Acta biomaterialia · 2022Review
- Cells and material-based strategies for regenerative endodontics.Bioactive materials · 2022Review
- Proteolytic activity and degradation of bovine versus human dentin matrices.Journal of applied oral science : revista FOB · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
objectiveTo compare proteomics and biological function of human dentin matrix molecules (hDMMs) and bovine dentin matrix molecules (bDMMs).
designDentin powder from human or bovine teeth (n = 4) was demineralized in 10% (v/v) ethylenediaminetetraacetic acid for 7 days. The extracts were dialyzed, lyophilized and proteins were characterized using liquid chromatography-tandem mass spectrometry and shotgun proteomic analysis. To study biological function, mouse-derived undifferentiated dental pulp cells (OD21) were treated with 0.01, 0.1 or 1 μg/mL of hDMMs or bDMMs and proliferation was measured after 24 hours and 48 hours using 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell migration was assessed after 24 hours using a Boyden chamber. Alizarin Red S staining was used to evaluate mineral formation.
resultsThere were 307 proteins identified, of which 93 proteins were common to both species. Gene Ontology functional analysis demonstrated similar pattern of biological process in both species which consisted mainly of tissue development and biomineralization. hDMMs and bDMMs both enhanced cell proliferation. After 24 hours, all concentrations of bDMMs promoted cell proliferation (p ≤ 0.05), while hDMMs did not affect proliferation. After 48 hours, groups with 1μg/mL of bDMMs and 0.01μg/mL of hDMMs had increased cell proliferation compared to control (p ≤ 0.0001). All concentrations of hDMMs and bDMMs enhanced cell migration and mineralization (p ≤ 0.0001).
conclusionbDMMs has similar biological functions as hDMMs. Moreover, bDMMs stimulated cell proliferation, migration and differentiation similar to hDMMs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.