Evidence map›Paper›PMID 32931912›Full record

ArticleBioorganic & medicinal chemistry letters2020

Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors.

Seungheon Lee, Angela F Ku, Mohana Rao Vippila, Yong Wang, Minjia Zhang, Xingyou Wang, Lizbeth Hedstrom, Gregory D Cuny

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Approaches Towards Better Immunosuppressive Agents.Current topics in medicinal chemistry · 2024
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Seungheon LeeDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX 77204, USA.
Angela F KuDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX 77204, USA; Department of Chemistry, University of Houston, Health Building 2, Houston, TX 77204, USA.
Mohana Rao VippilaDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX 77204, USA.
Yong WangDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX 77204, USA.
Minjia ZhangDepartments of Biology, 415 South St., Waltham, MA 02454, USA.
Xingyou WangDepartments of Biology, 415 South St., Waltham, MA 02454, USA.
Lizbeth HedstromDepartments of Biology, 415 South St., Waltham, MA 02454, USA; Chemistry, Brandeis University, 415 South St., Waltham, MA 02454, USA.
Gregory D CunyDepartment of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX 77204, USA. Electronic address: gdcuny@central.uh.edu.
University of Houston · USBrandeis University · US

Funding

IMPDH inhibitors for the treatment of Cryptosporidium infectionsR01AI125362 · NIAID · UNIVERSITY OF HOUSTON · PI CUNY, GREGORY D · 2016 to 2020
$3.8M
NIAID NIH HHS R01 AI125362
6 · The paper itself

Abstract

Inosine-5'-monophosphate dehydrogenase (IMPDH) is a potential target for microorganisms. However, identifying inhibitor design determinants for IMPDH orthologs continues to evolve. Herein, a series of mycophenolic anilide inhibitors of Cryptosporidium parvum and human IMPDHs are reported. Furthermore, molecular docking of 12 (e.g. SH-19; CpIMPDH K

Indexed as

AnilidesAntiparasitic AgentsBinding SitesCryptosporidiosisCryptosporidium parvumEnzyme InhibitorsHumansIMP DehydrogenaseMolecular Docking SimulationPhenolsAnilidesAntiparasitic AgentsEnzyme InhibitorsIMP DehydrogenasePhenolsBinding modeCryptosporidium parvumIMPDHInhibitorInosine-5’-monophosphate dehydrogenase

Identifiers

PMID32931912
PMCPMC9511823
OpenAlexW3086257574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.