Evidence map›Paper›PMID 32931794›Full record

ArticleToxicology and applied pharmacology2020

Biological effects of inhaled hydraulic fracturing sand dust. VI. Cardiovascular effects.

Kristine Krajnak, Hong Kan, Kristen A Russ, Walter McKinney, Stacey Waugh, Wen Zheng, Michael L Kashon, Claud Johnson, Jared Cumpston, Jeffrey S Fedan

Open access · greenAbstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  4. Spatiotemporal Correlation Analysis of Hydraulic Fracturing and Stroke in the United States.International journal of environmental research and public health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kristine KrajnakHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America. Electronic address: ksk1@cdc.gov.
Hong KanHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America.
Kristen A RussHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America.
Walter McKinneyHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America.
Stacey WaughHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America.
Wen ZhengHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America.
Michael L KashonHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America.
Claud JohnsonHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America.
Jared CumpstonHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America.
Jeffrey S FedanHealth Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, United States of America.
National Institute for Occupational Safety and Health · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Laura F. Gibson · 2012 to 2026
$81.0M
Intramural CDC HHS CC999999NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Hydraulic fracturing is used to access oil and natural gas reserves. This process involves the high-pressure injection of fluid to fracture shale. Fracking fluid contains approximately 95% water, chemicals and 4.5% fracking sand. Workers may be exposed to fracking sand dust (FSD) during the manipulation of the sand, and negative health consequences could occur if FSD is inhaled. In the absence of any information about its potential toxicity, a comprehensive rat animal model study (see Fedan et al., 2020) was designed to investigate the bioactivities of several FSDs in comparison to MIN-U-SIL® 5, a respirable α-quartz reference dust used in previous animal models of silicosis, in several organ systems. The goal of this study was to assess the effects of inhalation of one FSD, i.e., FSD 8, on factors and tissues that affect cardiovascular function. Male rats were exposed to 10 or 30 mg/m

Indexed as

DustHydraulic FrackingSandAdministration, InhalationAnimalsBlood PressureCardiovascular SystemHeart RateHydrogen PeroxideKidneyMaleMicrovesselsMyocardiumNitratesNitritesRats, Sprague-DawleyDustHydrogen PeroxideNitratesNitritesSandBlood pressureHeart rate variabilityOxidative stressRenal injuryVasoconstrictionVasodilation

Identifiers

PMID32931794
PMCPMC7673239
OpenAlexW3086018571

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.