Evidence map›Paper›PMID 32931793›Full record

ArticleToxicology and applied pharmacology2020

Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury.

Melissa L Wilkinson, Elena Abramova, Changjiang Guo, James G Gow, Alexa Murray, Adolf Koudelka, Veronika Cechova, Bruce A Freeman, Andrew J Gow

Open access · greenAbstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Nitro Fatty Acids (NOMolecules (Basel, Switzerland) · 2021
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Melissa L WilkinsonDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Elena AbramovaDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Changjiang GuoDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
James G GowDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Dartmouth College, Hanover, NH 03755, USA.
Alexa MurrayDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.
Adolf KoudelkaDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA 15213, USA.
Veronika CechovaDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA 15213, USA.
Bruce A FreemanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, 3550 Terrace St, Pittsburgh, PA 15213, USA.
Andrew J GowDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA; Environmental and Occupational Health Sciences Institute, Rutgers, The State University of New Jersey, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA. Electronic address: gow@pharmacy.rutgers.edu.
Rutgers, The State University of New Jersey · USUniversity of Pittsburgh · US

Funding

Vascular Subphenotypes of Lung DiseaseP01HL103455 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GLADWIN, MARK T · 2011 to 2020
$26.1M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Redox-Derived Pulmonary Anti-Inflammatory MediatorsR01HL064937 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN · 2000 to 2015
$5.6M
Anti-Inflammatory Lipid Mediators in AsthmaR01HL132550 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FREEMAN, BRUCE ALAN, HOLGUIN, FERNANDO · 2016 to 2019
$2.9M
NO-Modified Biomolecules and Pulmonary SignalingR01HL086621 · NHLBI · RUTGERS, THE STATE UNIV OF N.J. · PI GOW, ANDREW J · 2008 to 2016
$2.8M
NHLBI NIH HHS P01 HL103455NHLBI NIH HHS R01 HL064937NHLBI NIH HHS R01 HL086621NHLBI NIH HHS R01 HL132550NIEHS NIH HHS T32 ES007148
6 · The paper itself

Abstract

Fatty acid nitroalkenes are reversibly-reactive electrophiles, endogenously detectable at nM concentrations, displaying anti-inflammatory actions. Nitroalkenes like 9- or 10-nitro-octadec-9-enoic acid (e.g. nitro-oleic acid, OA-NO

Indexed as

BleomycinAcute Lung InjuryAlkenesAnimalsBronchoalveolar Lavage FluidFatty AcidsInflammationLeukocyte Common AntigensLungMacrophages, AlveolarMaleMesenchymal Stem CellsMiceMice, Inbred C57BLPhospholipidsWeight LossAlkenesBleomycinFatty AcidsLeukocyte Common AntigensPhospholipidsZEB1 protein, mouseZinc Finger E-box-Binding Homeobox 1Acute Lung InjuryBleomycinInflammationMacrophageNitroalkeneNitro-Oleic Acid

Identifiers

PMID32931793
PMCPMC7662837
OpenAlexW3085195347

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.