ArticleOpen biology2020
Metabolomics of human fasting: new insights about old questions.
Article in Open biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Interpretation of Pharmacometabolomics Results: Fingerprint of Drug Exposure or Confounder Effects? Insights from a Urinary Metabolomics Study with Voriconazole in Healthy Participants.International journal of molecular sciences · 2026Trial
- Electroconvulsive Treatment for Depression Alters Mitochondrial Serum Metabolites.Biological psychiatry global open science · 2026Article
- Obesity-derived metabolites modulate anti-tumor immunity in the tumor microenvironment: from mechanisms to clinical applications.BMC medicine · 2026Review
- Article
- LC-MS-Based Untargeted Metabolic Profiling in Plasma Following Dapagliflozin Administration in Healthy Volunteers.Metabolites · 2025Article
- Short-term dietary methionine restriction with high fat diet counteracts metabolic dysfunction in male mice.Physiological reports · 2025Article
- Dietary content and eating behavior in ulcerative colitis: a narrative review and future perspective.Nutrition journal · 2025Review
- Metabolome-wide Mendelian randomization for age at menarche and age at natural menopause.Genome medicine · 2024Article
- Metabolomics of Ramadan fasting and associated risk of chronic diseases.The American journal of clinical nutrition · 2024Observational
- Low glycemic index diet restrains epileptogenesis in a gender-specific fashion.Cellular and molecular life sciences : CMLS · 2023Article
- Untargeted Analysis of Serum Metabolomes in Dogs with Exocrine Pancreatic Insufficiency.Animals : an open access journal from MDPI · 2023Article
- Safe and Effective Antioxidant: The Biological Mechanism and Potential Pathways of Ergothioneine in the Skin.Molecules (Basel, Switzerland) · 2023Review
- Changes of androgen and corticosterone metabolites excretion and conversion in cystic fibrosis.Frontiers in endocrinology · 2023Article
- A Comprehensive Mass Spectrometry-Based Workflow for Clinical Metabolomics Cohort Studies.Metabolites · 2022Article
- Short-Term Fasting Attenuates Overall Steroid Hormone Biosynthesis in Healthy Young Women.Journal of the Endocrine Society · 2022Article
- Ergothioneine: A Stress Vitamin with Antiaging, Vascular, and Neuroprotective Roles?Antioxidants & redox signaling · 2022Review
- Ramadan diurnal intermittent fasting is associated with significant plasma metabolomics changes in subjects with overweight and obesity: A prospective cohort study.Frontiers in nutrition · 2022Article
- Alteration in glucocorticoids secretion and metabolism in patients affected by cystic fibrosis.Frontiers in endocrinology · 2022Article
- Long-term fasting: Multi-system adaptations in humans (GENESIS) study-A single-arm interventional trial.Frontiers in nutrition · 2022Article
- Whole Blood Metabolomics in Aging Research.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since ancient days, human fasting has been performed for religious or political reasons. More recently, fasting has been employed as an effective therapy for weight reduction by obese people, and numerous studies have investigated the physiology of fasting by obese subjects. Well-established fasting markers (butyrates, BCAAs and carnitines) were considered essential energy substitutes after glycogen storage depletion. However, a recently developed metabolomic approach has unravelled previously unappreciated aspects of fasting. Surprisingly, one-third (44) of 120 metabolites investigated increase during 58 h of fasting, including antioxidative metabolites (carnosine, ophthalmic acid, ergothioneine and urates) and metabolites of entire pathways, such as the pentose phosphate pathway. Signalling metabolites (3-hydroxybutyrate and 2-oxoglutarate) and purines/pyrimidines may also serve as transcriptional modulators. Thus, prolonged fasting activates both global catabolism and anabolism, reprogramming metabolic homeostasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.