Evidence map›Paper›PMID 32931637›Full record

ArticleCancer medicine2020

Covid-19 in patients with hematological and solid cancers at a Comprehensive Cancer Center in Germany.

Khalid Shoumariyeh, Francesca Biavasco, Gabriele Ihorst, Siegbert Rieg, Alexandra Nieters, Winfried V Kern, Cornelius Miething, Justus Duyster, Monika Engelhardt, Hartmut Bertz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
2.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Khalid ShoumariyehDepartment of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.ORCID 0000-0001-7969-1972
Francesca BiavascoDepartment of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Gabriele IhorstClinical Trials Unit Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Siegbert RiegDivision of Infectious Diseases, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Alexandra NietersInstitute for Immunodeficiency, Medical Center, University of Freiburg, Freiburg, Germany.
Winfried V KernDivision of Infectious Diseases, Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Cornelius MiethingDepartment of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Justus DuysterDepartment of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Monika EngelhardtDepartment of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Hartmut BertzDepartment of Medicine I, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
University of Freiburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with cancer are considered a high-risk group for viral pneumonia, with an increased probability of fatal outcome. Here, we investigated the clinical characteristics and outcome of patients with solid and hematological cancers and concomitant Covid-19 at a Comprehensive Cancer Center in a Covid-19 hotspot area in Germany.

methodsWe performed a retrospective single center cohort study of 39 patients with hematological and solid cancers who were hospitalized at the University Hospital Freiburg for Covid-19. Using univariate and multivariate Cox regression models we compared time to severe events and overall survival to an age-matched control cohort of 39 patients with confirmed Covid-19 without a cancer diagnosis.

resultsIn the cancer cohort 29 patients had a diagnosis of a solid tumor, and 10 had a hematological malignancy. In total, eight patients (21%) in the cancer and 14 patients (36%) from the noncancer cohort died during the observation period. Presence of a malignancy was not significantly associated with survival or time to occurrence of severe events. Major influences on mortality were high IL-6 levels at Covid-19 diagnosis (HR = 6.95, P = .0121) and age ≥ 65 years (HR = 6.22, P = .0156).

conclusionsCompared to an age-matched noncancer cohort, we did not observe an association between a cancer diagnosis and a more severe disease course or higher fatality rate in patients with Covid-19. Patients with a hematological malignancy showed a trend towards a longer duration until clinical improvement and longer hospitalization time compared to patients with a solid cancer. Cancer per se does not seem to be a confounder for dismal outcome in Covid-19.

Indexed as

AgedAged, 80 and overBetacoronavirusCoronavirus InfectionsCOVID-19FemaleGermanyHematologic NeoplasmsHospitalizationHumansMaleMiddle AgedNeoplasmsOncology Service, HospitalPandemicsPneumonia, Viralcancer managementepidemiologyepidemiology and preventionviral infection

Identifiers

PMID32931637
PMCPMC7666742
OpenAlexW3086117876

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.