Evidence map›Paper›PMID 32931541›Full record

ReviewNatural product reports2021

An invocation for computational evaluation of isomerization transforms: cationic skeletal reorganizations as a case study.

Alexander W Schuppe, Yannan Liu, Timothy R Newhouse

Abstract readReview
In one paragraph

Review in Natural product reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. JACS Au · 2024
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexander W SchuppeDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06511-8107, USA. timothy.newhouse@yale.edu.
Yannan Liu
Timothy R Newhouse

Funding

Synthesis of Neurologically Active Small MoleculesR01GM118614 · NIGMS · YALE UNIVERSITY · PI NEWHOUSE, TIMOTHY · 2017 to 2025
$3.1M
NIGMS NIH HHS R01 GM118614
6 · The paper itself

Abstract

Covering: 2010 to 2020This review article describes how cationic rearrangement reactions have been used in natural product total synthesis over the last decade as a case study for the many productive ways by which isomerization reactions are enabling for synthesis. This review argues that isomerization reactions in particular are well suited for computational evaluation, as relatively simple calculations can provide significant insight.

Indexed as

BenzofuransBenzophenonesBenzoquinonesBiological ProductsCationsCyclizationDiterpenes, KauraneIndole AlkaloidsIsomerismLupanesPentacyclic TriterpenesSesquiterpenesStilbenesTerpenes7-epiclusianoneaglafolineBenzofuransBenzophenonesBenzoquinonesBiological ProductsCationsDiterpenes, KauranegoniomitineIndole AlkaloidsLupaneslupeolpaucifloral FPentacyclic Triterpenespestalotiopsin Apsiguadial BSesquiterpenessteviolStilbenesTerpenes

Identifiers

PMID32931541
PMCPMC7956923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.