ArticleJournal of proteome research2020
Research on the Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, According to the HUPO Human Proteome Project.
Article in Journal of proteome research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Ethical Principles, Constraints and Opportunities in Clinical Proteomics.Molecular & cellular proteomics : MCP · 2021Pooled it
- Comprehensive Proteomic Profiling of Human Myocardium Reveals Signaling Pathways Dysregulated in Hypertrophic Cardiomyopathy.Journal of the American College of Cardiology · 2024Article
- SpliceProt 2.0: A Sequence Repository of Human, Mouse, and Rat Proteoforms.International journal of molecular sciences · 2024Article
- How Can Proteomics Help to Elucidate the Pathophysiological Crosstalk in Muscular Dystrophy and Associated Multi-System Dysfunction?Proteomes · 2024Article
- Global detection of human variants and isoforms by deep proteome sequencing.Nature biotechnology · 2023Article
- Mass Spectrometry-Based Proteomic Technology and Its Application to Study Skeletal Muscle Cell Biology.Cells · 2023Review
- Strategies for Conditional Regulation of Proteins.JACS Au · 2023Review
- Evolution of Protein Functional Annotation: Text Mining Study.Journal of personalized medicine · 2022Article
- How Far Are We from the Completion of the Human Protein Interactome Reconstruction?Biomolecules · 2022Article
- The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences.Nucleic acids research · 2022Article
- Mouse Organ-Specific Proteins and Functions.Cells · 2021Article
- Advances and Utility of the Human Plasma Proteome.Journal of proteome research · 2021Review
- Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project.Journal of proteome research · 2021Article
- The Arabidopsis PeptideAtlas: Harnessing worldwide proteomics data to create a comprehensive community proteomics resource.The Plant cell · 2021Article
- Proximity labeling and other novel mass spectrometric approaches for spatiotemporal protein dynamics.Expert review of proteomics · 2021Review
- Proteomes Are of Proteoforms: Embracing the Complexity.Proteomes · 2021Review
- The human melanoma proteome atlas-Defining the molecular pathology.Clinical and translational medicine · 2021Article
- A Multi-Omics Study of Human Testis and Epididymis.Molecules (Basel, Switzerland) · 2021Article
- Proteomics, Personalized Medicine and Cancer.Cancers · 2021Review
- Proteome-based pathology: the next frontier in precision medicine.Expert review of precision medicine and drug development · 2021Article
Corrections and comments
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Authors and funding
16 authors at 15 institutions in 9 countries.
Funding
Abstract
According to the 2020 Metrics of the HUPO Human Proteome Project (HPP), expression has now been detected at the protein level for >90% of the 19 773 predicted proteins coded in the human genome. The HPP annually reports on progress made throughout the world toward credibly identifying and characterizing the complete human protein parts list and promoting proteomics as an integral part of multiomics studies in medicine and the life sciences. NeXtProt release 2020-01 classified 17 874 proteins as PE1, having strong protein-level evidence, up 180 from 17 694 one year earlier. These represent 90.4% of the 19 773 predicted coding genes (all PE1,2,3,4 proteins in neXtProt). Conversely, the number of neXtProt PE2,3,4 proteins, termed the "missing proteins" (MPs), was reduced by 230 from 2129 to 1899 since the neXtProt 2019-01 release. PeptideAtlas is the primary source of uniform reanalysis of raw mass spectrometry data for neXtProt, supplemented this year with extensive data from MassIVE. PeptideAtlas 2020-01 added 362 canonical proteins between 2019 and 2020 and MassIVE contributed 84 more, many of which converted PE1 entries based on non-MS evidence to the MS-based subgroup. The 19 Biology and Disease-driven B/D-HPP teams continue to pursue the identification of driver proteins that underlie disease states, the characterization of regulatory mechanisms controlling the functions of these proteins, their proteoforms, and their interactions, and the progression of transitions from correlation to coexpression to causal networks after system perturbations. And the Human Protein Atlas published Blood, Brain, and Metabolic Atlases.
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Registered trials
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