ArticleACS nano2020
Exosome-Mediated Crosstalk between Keratinocytes and Macrophages in Cutaneous Wound Healing.
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Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.
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125citing papers in PubMed
9.1field-weighted citation impact, top 1% of its field
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Who cites it
125 citing papers in PubMed, 202 citations in OpenAlex.
- Electrical Stimulation-Induced Modulation of Small Extracellular Vesicles in Regenerative Therapy.Tissue engineering and regenerative medicine · 2026Review
- ATF7 drives diabetic wound healing via NOTCH1 repression and N1ICD-dependent macrophage polarization control.JCI insight · 2026Article
- Laser-induced skin microenvironment remodeling via exosomal CEBPA-mediated crosstalk between keratinocyte and fibroblast.Journal of nanobiotechnology · 2026Article
- Diabetic Wound Vasculopathy and Neuropathy: Spotlight on Wound Lipid Signaling.Advances in wound care · 2026Review
- Breast cancer cell-derived extracellular vesicles accelerate collagen fibrillogenesis and integrate into the matrix.Materials today. Bio · 2026Article
- The Role of Endothelial Cell-Derived Extracellular Vesicles in Modulating Fibroblast Function in Skin Wound Healing.The Journal of investigative dermatology · 2026Article
- Labeling, isolation and characterization of cell-type-specific exosomes derived from mouse skin tissue.Nature protocols · 2026Review
- Macrophage Extracellular Vesicles: Therapeutic Strategies for Corneal Fibrosis in Rare Diseases.Biomolecules · 2026Review
- Age-dependent effects of fibroblast-derived exosomes on keratinocyte differentiation.Biogerontology · 2026Article
- Mapping GlycoRNAs on an Exosomal Surface.Journal of the American Chemical Society · 2026Article
- Reversing diabetic wound stagnation: macrophage polarization dysregulation as a therapeutic linchpin from pathogenesis to precision interventions.Burns & trauma · 2026Review
- Extracellular vesicles in atopic dermatitis: unraveling pathogenic mediators and engineering therapeutic vectors.Frontiers in immunology · 2026Review
- Stem cell-derived secretome: a novel strategy for wound healing.Frontiers in pharmacology · 2026Review
- Role of Extracellular Vesicles in Skin Barrier Repair: Applications in Atopic Dermatitis and Chronic Wounds.International journal of nanomedicine · 2026Review
- Glucose-Responsive PEGDA-GelMA-MPBA Hydrogel Loaded with Exosomes Promotes Diabetic Wound Healing.Journal of diabetes research · 2026Article
- Application and Advances of Cell Membrane-Coated Nanoparticles in Diabetic Wound Healing.International journal of nanomedicine · 2026Review
- Roles of exosomal miRNAs from different sources in knee osteoarthritis: exercise-regulated skeletal muscle-derived exosomal miRNAs as a prospective therapeutic avenue.Frontiers in medicine · 2026Review
- Plant-derived extracellular vesicles in diabetic wound healing: mechanisms, therapeutic implications and future perspectives.Journal of materials science. Materials in medicine · 2025Review
- Direct in vivo reprogramming to relieve tissue ischemia via induced vasculogenesis.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Immunomodulatory Mechanisms of Chronic Wound Healing: Translational and Clinical Relevance.MedComm · 2025Review
65 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors at 6 institutions in 3 countries.
Xiaoju ZhouIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.ORCID 0000-0003-0797-1312
Brooke A BrownDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Amanda P SiegelIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.ORCID 0000-0003-4112-0212
Mohamed S El MasryIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.ORCID 0000-0002-2686-1509
Xuyao ZengDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Woran SongDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.
Amitava DasIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Puneet KhandelwalIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.ORCID 0000-0001-7204-9397
Andrew ClarkIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Kanhaiya SinghIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Poornachander R GudaIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.ORCID 0000-0003-2295-9637
Mahadeo GorainIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Lava TimsinaIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.ORCID 0000-0001-7493-5843
Yi XuanIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.ORCID 0000-0003-4795-957X
Stephen C JacobsonDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0003-2415-041X
Milos V NovotnyDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0001-5530-7059
Sashwati RoyIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.
Mangilal AgarwalIntegrated Nanosystems Development Institute, Indiana University-Purdue University, Indianapolis, Indiana 46202, United States.ORCID 0000-0003-3039-0073
Robert J LeeDivision of Pharmaceutics and Pharmacology, The Ohio State University, Columbus, Ohio 43210, United States.
Chandan K SenIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.ORCID 0000-0003-3151-5202
David E ClemmerDepartment of Chemistry, Indiana University, Bloomington, Indiana 47405, United States.ORCID 0000-0003-4039-1360
Subhadip GhatakIndiana Center for Regenerative Medicine & Engineering, Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202, United States.ORCID 0000-0001-5641-3902
Indiana University School of MedicineIndiana University Bloomington · USIndiana University – Purdue University Indianapolis · USThe Ohio State University · USWuhan University · CNZagazig University · EG
Funding
Vitamin E Neuroprotection: Novel Molecular MechanismsR01NS042617 · NINDS · OHIO STATE UNIVERSITY · PI SEN, CHANDAN K · 2002 to 2021
$3.9MWound Healing Endpoint and RecurrenceR01NR015676 · NINR · OHIO STATE UNIVERSITY · PI GORDILLO, GAYLE M, ROY, SASHWATI · 2015 to 2019
$2.6MGraduate Training Program in Quantitative and Chemical Biology at Indiana University BloomingtonT32GM131994 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI JARED C LEWIS · 2019 to 2026
$2.4M15 Tesla Bruker solariX FTICR MSS10OD018507 · OD · OHIO STATE UNIVERSITY · PI WYSOCKI, VICKI H. · 2014 to 2014
$2.0MMechanisms Underlying Impaired Diabetic Wound HealingR01DK114718 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI ROY, SASHWATI · 2018 to 2021
$1.6MGraduate Program in Quantitative and Chemical Biology at Indiana University BloomT32GM109825 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI GIEDROC, DAVID P. · 2014 to 2018
$926kNanofabricated Devices and Nanomedicine Approaches for Wound HealingK25GM143572 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI XUAN, YI · 2021 to 2024
$624kNIDDK NIH HHS R01 DK114718NIGMS NIH HHS K25 GM143572NIGMS NIH HHS T32 GM109825NIGMS NIH HHS T32 GM131994NIH HHS S10 OD018507NINDS NIH HHS R01 NS042617NINR NIH HHS R01 NR015676
Abstract
Bidirectional cell-cell communication involving exosome-borne cargo such as miRNA has emerged as a critical mechanism for wound healing. Unlike other shedding vesicles, exosomes selectively package miRNA by SUMOylation of heterogeneous nuclear ribonucleoproteinA2B1 (hnRNPA2B1). In this work, we elucidate the significance of exosome in keratinocyte-macrophage crosstalk following injury. Keratinocyte-derived exosomes were genetically labeled with GFP-reporter (Exo
Indexed as
ExosomesAnimalsKeratinocytesMacrophagesMiceSkinWound Healingexosomekeratinocyte-targeted lipid nanoparticlesmacrophagetissue nanotransfectionwound healing
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