Evidence map›Paper›PMID 32931236›Full record

ArticleACS applied materials & interfaces2020

Nitric Oxide-Releasing Insert for Disinfecting the Hub Region of Tunnel Dialysis Catheters.

Joshua C Doverspike, Shale J Mack, Amy Luo, Blake Stringer, Shelby Reno, Marie S Cornell, Alvaro Rojas-Pena, Jianfeng Wu, Chuanwu Xi, Alexander Yevzlin and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. [Advances in Novel Disinfection Technologies for Biofilm-Associated Nosocomial Infections].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  3. Article
  4. Review
  5. Review
  6. ACS applied materials & interfaces · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Joshua C DoverspikeDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID http://orcid.org/0000-0002-6062-9607
Shale J MackDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Amy LuoDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Blake StringerDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.
Shelby RenoDepartment of Surgery, Extracorporeal Life Support Laboratory, University of Michigan, Ann Arbor, Michigan 48109, United States.
Marie S CornellDepartment of Surgery, Extracorporeal Life Support Laboratory, University of Michigan, Ann Arbor, Michigan 48109, United States.
Alvaro Rojas-PenaDepartment of Surgery, Extracorporeal Life Support Laboratory, University of Michigan, Ann Arbor, Michigan 48109, United States.
Jianfeng WuDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Chuanwu XiDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan 48109, United States.
Alexander YevzlinDepartment of Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
Mark E MeyerhoffDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID http://orcid.org/0000-0002-7841-281X
University of Michigan · US

Funding

Bactericidal, Nonthrombogenic Intravascular CathetersR01HL128337 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BARTLETT, ROBERT H., MEYERHOFF, MARK E · 2015 to 2018
$2.8M
NHLBI NIH HHS R01 HL128337
6 · The paper itself

Abstract

The use of tunneled dialysis catheters (TDCs) for patients in need of hemodialysis treatments (HDs) causes a significant number of bloodstream infections (BSIs), with very few viable preventative/treatment methods. Use of antibiotics is relatively ineffective due to the development of multidrug-resistant bacterial strains and the inability to penetrate bacterial biofilms. Nitric oxide (NO) is an endogenous gas molecule that has broad-spectrum antimicrobial/antibiofilm activity. In this study, the potential of creating a NO-releasing insert device that is attached onto the hub region cap of TDCs and locally releases NO within the TDC hub is evaluated for its antimicrobial/antibiofilm effectiveness. The NO-releasing insert contains the natural NO donor

Indexed as

Anti-Bacterial AgentsBiofilmsCatheters, IndwellingDisinfectantsDisinfectionHumansMicrobial Sensitivity TestsNitric OxidePseudomonas aeruginosaRenal DialysisSepsisStaphylococcus aureusAnti-Bacterial AgentsDisinfectantsNitric Oxideantibiofilmantimicrobialcathetersnitric oxideS-nitrosoglutathionezinc oxide nanoparticles

Identifiers

PMID32931236
PMCPMC8394517
OpenAlexW3087250703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.