Evidence map›Paper›PMID 32931122›Full record

ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2020

The evolution of Kraepelin's nosological principles.

Stephan Heckers, Kenneth S Kendler

Registry-linked trialAbstract read
In one paragraph

Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05130853 (Social Cognition Individualized Activities Lab), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05130853 nacompletednot on this mapstarted 2021, after this paper: background citation

Social Cognition Individualized Activities Lab (SoCIAL) for the Training of Social Cognition and Narrative Enhancement in Patients With Schizophrenia: A Randomized Controlled Study to Assess Efficacy and Generalization to Real-life Functioning

TypeinterventionalSponsorUniversity of Campania Luigi VanvitelliRan2021 to 2022Enrolled48ConditionsSchizophrenia, Schizo Affective DisorderArmsSocial Skills and Neurocognitive Individualized Training (SoCIAL), Treatmment-as-usual
3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. [Psychiatry as clinical neuroscience].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Review
  3. Overvalued Ideas: Conceptual Analysis and Literature Review.Behavioral sciences (Basel, Switzerland) · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Philosophy of psychiatry: theoretical advances and clinical implications.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Markers of Schizophrenia-A Critical Narrative Update.Journal of clinical medicine · 2022
    Review
  18. Klerman's "credo" reconsidered: neo-Kraepelinianism, Spitzer's views, and what we can learn from the past.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Stephan HeckersDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Kenneth S KendlerVirginia Institute of Psychiatric and Behavioral Genetics, and De-part-ment of Psychiatry, Medical College of Virginia/Virginia Commonwealth University, Richmond, VA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emil Kraepelin developed a new psychiatric nosology in the eight editions of his textbook. Previous papers have explored his construction of particular diagnoses, including dementia praecox and manic-depressive insanity. Here we are providing a close reading of his introductory textbook chapter, that presents his general principles of nosology. We identify three phases: 1) editions 1-4, in which he describes nosological principles in search of data; 2) editions 5-7, in which he declares the mature version of his nosological principles and develops new disease categories; 3) edition 8, in which he qualifies his nosological claims and allows for greater differentiation of psychiatric disorders. We propose that Kraepelin's nosology is grounded in three principles. First, psychiatry, like other sciences, deals with natural phenomena. Second, mental states cannot be reduced to neural states, but science will progress and will, ultimately, reveal how nature creates abnormal mental states and behavior. Third, there is a hierarchy of validators of psychiatric diagnoses, with the careful study of clinical features (signs, symptoms and course) being more important than neuropathologic and etiological studies. These three principles emerged over the course of the eight editions of Kraepelin's textbook and were informed by his own research and by available scientific methods. His scientific views are still relevant today: they have generated and, at the same time, constrained our current psychiatric nosology.

Indexed as

clinical picturesdisease formsKraepelinnatural kindspsychiatric nosologypsychiatry textbookpsychosesscientific naturalismvalidators

Identifiers

PMID32931122
PMCPMC7491624

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.