ArticleWorld psychiatry : official journal of the World Psychiatric Association (WPA)2020
Nature and prevalence of combinations of mental disorders and their association with excess mortality in a population-based cohort study.
Article in World psychiatry : official journal of the World Psychiatric Association (WPA), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 4 of them syntheses that pooled it.
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Who cites it
74 citing papers in PubMed, 4 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Guideline
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- A transdiagnostic network for psychiatric illness derived from atrophy and lesions.Nature human behaviour · 2023Pooled it
- How to improve the physical health of people with severe mental illness? A multicentric randomized controlled trial on the efficacy of a lifestyle group intervention.European psychiatry : the journal of the Association of European Psychiatrists · 2021Trial
- Mental disorders in childhood or adolescence and subsequent comprehensive school achievement.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Ensuring High Quality Oyster Care for People Experiencing Severe and Persistent Mental Illness - A Three-Phase Development of A Quality Monitoring Tool.Community mental health journal · 2026Article
- Questions on Medicines, Alcohol, and Illicit Drug Interactions in the Finnish AddictionLink Online Service: A Descriptive Analysis.Nordisk alkohol- & narkotikatidskrift : NAT · 2026Article
- Screening Performance of the DSM-5 Level 1 Cross-Cutting Symptom Measure to Detect Psychiatric Comorbidity Among Youth: A Community-Based Study.Early intervention in psychiatry · 2026Article
- Combinations of mental disorders and their association with mortality in the UK Biobank.BMC psychiatry · 2026Article
- Predictors of psychological symptom risk in older adults in Türkiye: the role of mental health literacy and demographic-clinical factors.BMC geriatrics · 2026Article
- Integrating physical healthcare into psychiatry for severe mental illness: A narrative review and position statement from the ECNP PAN-Health group.Neuroscience applied · 2026Review
- Opinion: On the reasons for underutilization of ECT in individuals with intellectual and developmental disability.Frontiers in psychiatry · 2026Article
- Metabolomic and gut microbial biomarkers of smoking cessation treatment in long-term drug therapy: a study protocol for a randomized controlled trial.Frontiers in psychiatry · 2026Article
- Patterns of Mental Disorders in a Large Child Psychiatric Sample (N = 65,363): A DREAMS Study.JAACAP open · 2025Article
- Identifying psychiatric morbidity and comorbidity patterns associated with COVID-19 mortality. A register-based cohort study from Catalonia.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Dietary intake and five types of mental disorders: a bidirectional Mendelian randomization study.BMC psychiatry · 2025Article
- Aligning forces to accelerate healthcare transformation: Insights from the UPMC learning community.Learning health systems · 2025Article
- From Education to Action-The Impact of Hepatitis C Micro-Elimination Education on Healthcare Provider Confidence and Linkage to Care: A Quasi-Experimental Study.Health science reports · 2025Article
- Addressing Tobacco Use Disorder in Individuals With Mental Health Disorders: The Critical Role of Nurses.Journal of advanced nursing · 2025Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nature and prevalence of combinations of mental disorders and their associations with premature mortality have never been reported in a comprehensive way. We describe the most common combinations of mental disorders and estimate excess mortality associated with these combinations. We designed a population-based cohort study including all 7,505,576 persons living in Denmark at some point between January 1, 1995 and December 31, 2016. Information on mental disorders and mortality was obtained from national registers. A total of 546,090 individuals (10.5%) living in Denmark on January 1, 1995 were diagnosed with at least one mental disorder during the 22-year follow-up period. The overall crude rate of diagnosis of mental disorders was 9.28 (95% CI: 9.26-9.30) per 1,000 person-years. The rate of diagnosis of additional mental disorders was 70.01 (95% CI: 69.80-70.26) per 1,000 person-years for individuals with one disorder already diagnosed. At the end of follow-up, two out of five individuals with mental disorders were diagnosed with two or more disorder types. The most prevalent were neurotic/stress-related/somatoform disorders (ICD-10 F40-F48) and mood disorders (ICD-10 F30-F39), which - alone or in combination with other disorders - were present in 64.8% of individuals diagnosed with any mental disorder. Mortality rates were higher for people with mental disorders compared to those without mental disorders. The highest mortality rate ratio was 5.97 (95% CI: 5.52-6.45) for the combination of schizophrenia (ICD-10 F20-F29), neurotic/stress-related/somatoform disorders and substance use disorders (ICD-10 F10-F19). Any combination of mental disorders was associated with a shorter life expectancy compared to the general Danish population, with differences in remaining life expectancy ranging from 5.06 years (95% CI: 5.01-5.11) to 17.46 years (95% CI: 16.86-18.03). The largest excess mortality was observed for combinations that included substance use disorders. This study reports novel estimates related to the "force of comorbidity" and provides new insights into the contribution of substance use disorders to premature mortality in those with comorbid mental disorders.
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