A novel genotyping technique for discriminating LVAS-associated high-frequency variants in SLC26A4 gene.

Chen Zhou, Xiangman Zou, Cuiying Peng, Guoqiang Gao, Zifen Guo

Open access · goldAbstract read

In one paragraph

Article in AMB Express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact, top 92% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chen ZhouInstitute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China.

Xiangman ZouInstitute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China.

Cuiying PengHunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang, Hunan, China.

Guoqiang GaoThe Second Affiliated Hospital, University of South China, Hengyang, Hunan, China.

Zifen GuoInstitute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan, China. guozifen@aliyun.com.ORCID http://orcid.org/0000-0003-3840-6295

University of South China · CN

Funding

the key project of the Education Department of Hunan Province No.19A419the Natural Science Foundation of Hunan Province No.2018JJ2350

6 · The paper itself

Abstract

An increasing number of biological and epidemiological evidence suggests that c.919-2A > G and c.2168A > G variants of solute carrier family 26, member 4 (SLC26A4) gene play a critical role in the development of large vestibular aqueduct syndrome (LVAS). In this study, we developed a rapid genotyping method for discriminating LVAS-associated high-frequency variants in SLC26A4 gene. The genotyping technique consists of 3' terminal exonuclease-resistant phosphorothioate-modified allele specific primer extension mediated by exo

Indexed as

Exo+ polymeraseLarge vestibular aqueduct syndromePhosphorothioate modificationSolute carrier family 26 member 4

Identifiers

PMID32930899

DOI10.1186/s13568-020-01102-7

PMCPMC7492351

OpenAlexW3085803474

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.