ArticleCurrent microbiology2020
Antibacterial Activity of Halophilic Bacteria Against Drug-Resistant Microbes Associated with Diabetic Foot Infections.
Article in Current microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Genotypes, antibiotic resistance, and virulence diversity among Klebsiella pneumoniae species complex isolates in Taiwan.Gut pathogens · 2026Article
- Exploring Marinilactibacillus sp from Lake Urmia as a novel halophilic source of antibacterial bioactive compounds.Extremophiles : life under extreme conditions · 2026Article
- Isolation, screening, and molecular identification of culturable halophilic bacteria with enzymatic and antimicrobial potential from the saline soils of Arzew salt lake, Algeria.Extremophiles : life under extreme conditions · 2025Article
- Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 22: Suitability of taxonomic units notified to EFSA until March 2025.EFSA journal. European Food Safety Authority · 2025Article
- The Threat of Bis(2-Ethylhexyl) Phthalate in Coastal and Marine Environments: Ecotoxicological Assays Using Tropical Species from Different Trophic Levels.International journal of environmental research and public health · 2025Article
- Beneficial Effects of ProbioticInternational journal of molecular sciences · 2024Article
- Dopamine promotesFrontiers in cellular and infection microbiology · 2024Article
- Bioprospecting of unexplored halophilic actinobacteria against human infectious pathogens.3 Biotech · 2023Review
- Draft genome sequence of Hahella sp. CR1 and its ability in producing cellulases for saccharifying agricultural biomass.Archives of microbiology · 2023Article
- Microbially Synthesized Polymer-Metal Nanoparticles Composites as Promising Wound Dressings to Overcome Methicillin-ResistancePolymers · 2023Article
- Isolation and screening ofIranian journal of microbiology · 2023Article
- Structural characterization, antioxidant and anti-uropathogenic potential of biogenic silver nanoparticles using brown seaweedFrontiers in microbiology · 2023Article
- Bioactive Efficacy of Novel Carboxylic Acid from HalophilicMetabolites · 2022Article
- Recent Antimicrobial Responses of Halophilic Microbes in Clinical Pathogens.Microorganisms · 2022Review
- Shallow Hydrothermal Vent Bacteria and Their Secondary Metabolites with a Particular Focus onMarine drugs · 2021Article
- Update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 14: suitability of taxonomic units notified to EFSA until March 2021.EFSA journal. European Food Safety Authority · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacteria causing diabetic foot infections (DFI) are chronic and generally multidrug resistant (MDR), which calls urgently for alternative antibacterials. The present study focused on potential metabolite producing bacteria from a saltpan environment and screened against MDR pathogens isolated from DFI patients. Molecular identification of the DFI pathogens provided Klebsiella quasivariicola, Staphylococcus argenteus, Escherichia coli, Staphylococcus hominis subsp. novobiosepticus, Bacillus australimaris, and Corynebacterium stationis. Among 34 isolated halophilic bacteria, the cell-free supernatant of strain PSH06 provided the largest inhibition zone of 23 mm against K. quasivariicola [D1], 21 mm against. S. argenteus [D2], 19 mm against E. coli [D3], and a minimum inhibition zone was found to be 14 mm against C. stationis [D8]. The potent activity providing stain confirmed as Pseudomonas aeruginosa through molecular identification. On the other hand, ethyl acetate extract of this strain showed excellent growth inhibition in MIC at 64 µg/mL against K. quasivariicola. Distressed cell membranes and vast dead cells were observed at MIC of ethyl acetate extract by SEM and CLSM against K.quasivariicola and E. coli. GC-MS profile of ethyl acetate extract exposed the occurrence of Bis (2-Ethylhexyl) Phthalate and n-Hexadecanoic acid and shows 100% toxic effect at 24 mg/mL by Artemia nauplii. The active extract fraction with above compounds derived from saltpan bacteria provided highest antibacterial efficacy against DFI-associated pathogens depicted with broad spectrum activity compared to standard antibiotics.
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