Evidence map›Paper›PMID 32930571›Full record

ArticleACS infectious diseases2020

Antifungal Susceptibility Testing of

Christopher Heuer, Heidi Leonard, Nadav Nitzan, Ariella Lavy-Alperovitch, Naama Massad-Ivanir, Thomas Scheper, Ester Segal

Open access · hybridAbstract read
In one paragraph

Article in ACS infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Christopher HeuerInstitute of Technical Chemistry, Leibniz University Hannover, 30167 Hannover, Germany.
Nadav Nitzan
Ariella Lavy-Alperovitch
Naama Massad-IvanirORCID 0000-0001-8964-9997
Thomas ScheperInstitute of Technical Chemistry, Leibniz University Hannover, 30167 Hannover, Germany.
Technion – Israel Institute of Technology · ILLeibniz University Hannover · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a demonstrated and paramount need for rapid, reliable infectious disease diagnostics, particularly those for invasive fungal infections. Current clinical determinations for an appropriate antifungal therapy can take up to 3 days using current antifungal susceptibility testing methods, a time-to-readout that can prove detrimental for immunocompromised patients and promote the spread of antifungal resistant pathogens. Herein, we demonstrate the application of intensity-based reflectometric interference spectroscopic measurements (termed iPRISM) on microstructured silicon sensors for use as a rapid, phenotypic antifungal susceptibility test. This diagnostic platform optically tracks morphological changes of fungi corresponding to conidia growth and hyphal colonization at a solid-liquid interface in real time. Using

Indexed as

Antifungal AgentsAspergillus nigerHumansMicrobial Sensitivity TestsSiliconSpectrum AnalysisAntifungal AgentsSiliconantifungal susceptibility testingAspergillus nigerfungal resistanceoptical sensorsensor

Identifiers

PMID32930571
PMCPMC7584364
OpenAlexW3087198201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.