ArticleChemMedChem2020
Towards the Prediction of Antimicrobial Efficacy for Hydrogen Bonded, Self-Associating Amphiphiles.
Article in ChemMedChem, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed.
- Article
- Amino acid appended supramolecular self-associating amphiphiles demonstrate dual activity against both MRSA and ovarian cancer.Chemical science · 2026Article
- An increased throughput workflow to identify ion transport and membrane lysis agents for antimicrobial discovery.Chemical science · 2026Article
- The effects of bioisostere substitution on the antimicrobial and physicochemical properties of supramolecular self-associating amphiphiles.RSC medicinal chemistry · 2026Article
- Dicarboxylate and dicarboxylic acid appended supramolecular self-associating amphiphiles as antimicrobial agents against high priority bacterial pathogens.Organic & biomolecular chemistry · 2025Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Towards the development of supramolecular self-associating amphiphiles as antibiofilm agents againstJournal of materials chemistry. B · 2025Article
- Supramolecular Self-Associating Amphiphiles Inhibit Biofilm Formation by the Critical Pathogens,ACS omega · 2024Article
- Advancements in antimicrobial nanoscale materials and self-assembling systems.Chemical Society reviews · 2022Review
- A water-soluble membrane transporter for biologically relevant cations.RSC advances · 2022Article
- Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of 'druggable' supramolecular self-associating antimicrobial amphiphiles.Chemical science · 2022Article
- Squaramide-Based Self-Associating Amphiphiles for Anion Recognition.ChemPlusChem · 2021Article
- Supramolecular self-associating amphiphiles (SSAs) as nanoscale enhancers of cisplatin anticancer activity.RSC advances · 2021Article
- Supramolecular self-associating amphiphiles (SSAs) as enhancers of antimicrobial agents towardsRSC advances · 2021Article
- Towards the Prediction of Antimicrobial Efficacy for Hydrogen Bonded, Self-Associating Amphiphiles.ChemMedChem · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Herein we report 50 structurally related supramolecular self-associating amphiphilic (SSA) salts and related compounds. These SSAs are shown to act as antimicrobial agents, active against model Gram-positive (methicillin-resistant Staphylococcus aureus) and/or Gram-negative (Escherichia coli) bacteria of clinical interest. Through a combination of solution-state, gas-phase, solid-state and in silico measurements, we determine 14 different physicochemical parameters for each of these 50 structurally related compounds. These parameter sets are then used to identify molecular structure-physicochemical property-antimicrobial activity relationships for our model Gram-negative and Gram-positive bacteria, while simultaneously providing insight towards the elucidation of SSA mode of antimicrobial action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.