ArticleCirculation2020
Complex Arrhythmia Syndrome in a Knock-In Mouse Model Carrier of the N98S
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Article in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
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Who cites it
20 citing papers in PubMed, 20 citations in OpenAlex.
- Cardiac α4β2 nicotinic receptors as a therapeutic target for fatal ventricular arrhythmias.European heart journal · 2026Article
- Calmodulin mutation N54I causes autosomal dominant CPVT in mice.bioRxiv : the preprint server for biology · 2026Article
- Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models.Signal transduction and targeted therapy · 2026Article
- Case Report: Overlap of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia in two Chinese children withFrontiers in pediatrics · 2026Article
- Calmodulin D133H Disrupts CaCells · 2025Article
- Enrichment of mutant calmodulin protein in a murine model of a human calmodulinopathy.JCI insight · 2025Article
- Arrhythmogenic calmodulin variants D131E and Q135P disrupt interaction with the L-type voltage-gated CaActa physiologica (Oxford, England) · 2025Article
- Antisense Oligonucleotide Therapy for Calmodulinopathy.Circulation · 2024Article
- Advancements in the diagnosis and management of premature ventricular contractions in pediatric patients.Frontiers in pediatrics · 2024Review
- Molecular Pathways and Animal Models of Arrhythmias.Advances in experimental medicine and biology · 2024Article
- Sex and Gene Influence Arrhythmia Susceptibility in Murine Models of Calmodulinopathy.Circulation. Arrhythmia and electrophysiology · 2023Article
- Human calmodulin mutations cause arrhythmia and affect neuronal function in C. elegans.Human molecular genetics · 2023Article
- Genome Editing and Cardiac Arrhythmias.Cells · 2023Review
- NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling.The Journal of clinical investigation · 2023Article
- Understanding Calmodulin Variants Affecting Calcium-Dependent Inactivation of L-Type Calcium Channels through Whole-Cell Simulation of the Cardiac Ventricular Myocyte.Biomolecules · 2022Article
- De novo mutations in childhood cases of sudden unexplained death that disrupt intracellular CaProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Network Pharmacology-Based Systematic Analysis of Molecular Mechanisms of Dingji Fumai Decoction for Ventricular Arrhythmia.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Dynamic and conventional electrocardiograms for diagnosing arrhythmic coronary atherosclerotic heart disease: a comparative analysis.American journal of translational research · 2021Article
- Calmodulinopathy in inherited arrhythmia syndromes.Tzu chi medical journalReview
- The link between abnormalities of calcium handling proteins and catecholaminergic polymorphic ventricular tachycardia.Tzu chi medical journalReview
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Authors and funding
9 authors at 4 institutions in 3 countries.
Wen-Chin Tsai *The Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine (W.-C.T., S.G., M.A.O., J.Y., C.-P.C. P.-S.C., M.R.), Indiana University School of Medicine, Indianapolis.
Shuai Guo *The Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine (W.-C.T., S.G., M.A.O., J.Y., C.-P.C. P.-S.C., M.R.), Indiana University School of Medicine, Indianapolis.
Michael A OlaopaThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine (W.-C.T., S.G., M.A.O., J.Y., C.-P.C. P.-S.C., M.R.), Indiana University School of Medicine, Indianapolis.
Loren J FieldWells Center for Pediatric Research, Department of Pediatrics (L.J.F., M.R.), Indiana University School of Medicine, Indianapolis.
Jin YangThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine (W.-C.T., S.G., M.A.O., J.Y., C.-P.C. P.-S.C., M.R.), Indiana University School of Medicine, Indianapolis.
Changyu ShenBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (C.S.).
Ching-Pin ChangThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine (W.-C.T., S.G., M.A.O., J.Y., C.-P.C. P.-S.C., M.R.), Indiana University School of Medicine, Indianapolis.
Peng-Sheng ChenThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine (W.-C.T., S.G., M.A.O., J.Y., C.-P.C. P.-S.C., M.R.), Indiana University School of Medicine, Indianapolis.
Michael RubartThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine (W.-C.T., S.G., M.A.O., J.Y., C.-P.C. P.-S.C., M.R.), Indiana University School of Medicine, Indianapolis.
Indiana University – Purdue University Indianapolis · USBeth Israel Deaconess Medical Center · USHarbin Medical University · CNTzu Chi University · TW
Funding
WAVE DYNAMICS IN NORMAL AND DISEASED RABBIT HEARTSP01HL078931 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WEISS, JAMES N · 2005 to 2015
$20.7MSK Current, beta-3 adrenoceptor activation and Sex Differences in Ventricular ArrhythmogenesisR01HL139829 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI PENG-SHENG CHEN, ZHILIN QU · 2018 to 2026
$4.5MLncRNA mechanism of heart failureR01HL121197 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI CHANG, CHING-PIN · 2014 to 2022
$3.8MUsing electrical nerve stimulation to control atrial fibrillation.OT2OD028190 · OD · INDIANA UNIVERSITY INDIANAPOLIS · PI CHEN, PENG-SHENG · 2019 to 2021
$2.3MHigh Resolution, Noninvasive Measurement and Functional Classification of Vagal Nerve Response Patterns in Relation to Gastroparesis Symptom Management using Gastric Electrical Stimulation TherapyOT2OD028183 · OD · PURDUE UNIVERSITY · PI CLEMENTS, ISAAC PERRY, EVERETT, THOMAS H · 2019 to 2021
$2.0MCardiomyocyte cell cycle activity in injured heartsR01HL132927 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI FIELD, LOREN J · 2017 to 2020
$1.6MSkin Sympathetic Nerve Activity and Cardiac ArrhythmiasR42DA043391 · NIDA · ARRHYTHMOTECH, LLC · PI EVERETT, THOMAS H · 2016 to 2017
$1.5MNHLBI NIH HHS P01 HL078931NHLBI NIH HHS R01 HL121197NHLBI NIH HHS R01 HL132927NHLBI NIH HHS R01 HL139829NIDA NIH HHS R42 DA043391NIH HHS OT2 OD028183NIH HHS OT2 OD028190
Abstract
backgroundCalmodulin mutations are associated with arrhythmia syndromes in humans. Exome sequencing previously identified a de novo mutation in
methodsMouse lines heterozygous for the Calm1
resultsTwo biologically independent knock-in mouse lines heterozygous for the Calm1
conclusionsHeterozygosity for the
Indexed as
CalmodulinMutation, MissenseAmino Acid SubstitutionAnimalsDisease Models, AnimalHeart VentriclesHumansMaleMiceMice, TransgenicMyocytes, CardiacPurkinje FibersSick Sinus SyndromeCalm1 protein, mouseCalmodulinarrhythmias, cardiaccalcium channelscalmodulinheart diseasesmodel, animal
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.