Evidence map›Paper›PMID 32929915›Full record

ArticleZhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery2020

[Application status of hypoxia mimetic agents in bone tissue engineering].

Sicong Ren, Yiping Liu, Yanlin Zhu, Yingying Wang, Manxuan Liu, Yanmin Zhou

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Sicong RenDepartment of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun Jilin, 130021, P.R.China.
Yiping LiuDepartment of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun Jilin, 130021, P.R.China.
Yanlin ZhuDepartment of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun Jilin, 130021, P.R.China.
Yingying WangDepartment of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun Jilin, 130021, P.R.China.
Manxuan LiuDepartment of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun Jilin, 130021, P.R.China.
Yanmin ZhouDepartment of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun Jilin, 130021, P.R.China.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo summarize the application status of hypoxia mimetic agents in bone tissue engineering.

methodsThe related literature about the hypoxia mimetic agents in bone tissue engineering was reviewed and analyzed. And the application status and progress of hypoxia mimetic agents in bone tissue engineering were retrospectively analyzed.

resultsHypoxia mimetic agents have the same effect as hypoxia in up-regulating the level of hypoxia inducible factor 1α (HIF-1α). The combination of hypoxia mimetic agents and scaffolds can up-regulate the level of HIF-1α in bone tissue engineering, thus promoting early vascularization and bone regeneration of the bone defect area, which provides a new idea for using bone tissue engineering to repair bone defect. At present, the commonly used hypoxia mimetic agents include iron chelating agents, oxoglutarate competitive analogues, proline hydroxylase inhibitors,

conclusionHypoxia mimetic agents have a wide application prospect in bone tissue engineering, but they have been used in bone tissue engineering for a short time, more attention should be paid to their possible side effects. In the future research, the hypoxia mimetic agents should be developed in the direction of higher targeting specificity and safety, and the exact mechanism of hypoxia mimetic agents in promoting bone regeneration should be further explored.

Indexed as

Bone and BonesTissue EngineeringBone RegenerationHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitRetrospective StudiesHypoxia-Inducible Factor 1, alpha Subunitbone repairBone tissue engineeringhypoxia mimetic agentsvascularization

Identifiers

PMID32929915
PMCPMC8171726
OpenAlexW3087481027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.