Evidence map›Paper›PMID 32929861›Full record

ArticleCNS neuroscience & therapeutics2021

Gut microbiota interacts with intrinsic brain activity of patients with amnestic mild cognitive impairment.

Ping Liu, Xi-Ze Jia, Yi Chen, Yang Yu, Kan Zhang, Ya-Jie Lin, Bao-Hong Wang, Guo-Ping Peng

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In one paragraph

Article in CNS neuroscience & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  17. Gut microbiome compositional and functional features associate with Alzheimer's disease pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ping LiuDepartment of Neurology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Xi-Ze JiaCenter for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China.
Yi ChenDepartment of Neurology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Yang YuDepartment of Neurology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Kan ZhangDepartment of Neurology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Ya-Jie LinDepartment of Neurology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Bao-Hong WangCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Guo-Ping PengDepartment of Neurology, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.ORCID 0000-0002-6706-8670

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo explore the potential relationships among gut microbiota (GM), local brain spontaneous activity, and neuropsychological characteristics in amnestic mild cognitive impairment (aMCI) patients.

methodsTwenty aMCI and 22 healthy control (HC) subjects were recruited. The GM composition was determined by 16S ribosomal RNA gene sequencing. Resting-state functional magnetic resonance imaging scans were performed, and fractional amplitude of low-frequency fluctuations (fALFF) was calculated across different frequencies. The Spearman or Pearson correlation analysis was used to analyze the relationship between spontaneous brain activity and cognitive function, and GM composition.

resultsaMCI patients had altered GM state and local spontaneous brain activity as compared with HC subjects. Correlation analysis showed that aMCI and HC groups had different "GM-intrinsic brain activity interaction" patterns. In aMCI group, at the typical band (0.01-0.08 Hz), the relative abundance (RA) of Bacteroides from phylum to genus level was negatively correlated with fALFF value of cerebellar vermis IV-V, and the Ruminococcaceae RA was negatively correlated with fALFF values of left lenticular nucleus and pallidum. The Clostridiaceae RA and Blautia RA were positively correlated with the left cerebellum lobules IV-V at the slow-4 band (0.027-0.073 Hz). The Veillonellaceae RA was positively correlated with fALFF values of left precentral gyrus at the slow-5 band (0.073-0.08 Hz). Correlation analysis showed that Clostridium members (Lachnospiraceae and Blautia) were positively, while Veillonellaceae was negatively, correlated with cognition test. Bacteroides was positively correlated with attention and computation, and negatively correlated with the three-stage command score.

conclusionsaMCI patients have a specific GM-intrinsic brain activity-cognitive function interaction pattern.

Indexed as

AgedAged, 80 and overAmnesiaBrainCase-Control StudiesCognitive DysfunctionCross-Sectional StudiesFemaleGastrointestinal MicrobiomeHumansMaleMiddle Agedamnestic mild cognitive impairmentgut microbiotainteractionresting-state functional magnetic resonance imaging

Identifiers

PMID32929861
PMCPMC7816203

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.