Evidence map›Paper›PMID 32929856›Full record

ArticleNeuromodulation : journal of the International Neuromodulation Society2021

Outcomes Associated With Infection of Chronic Pain Spinal Implantable Electronic Devices: Insights From a Nationwide Inpatient Sample Study.

Vasudha Goel, Varun Kumar, Shivani N Agrawal, Amol M Patwardhan, Mohab Ibrahim, Daniel C DeSimone, Eellan Sivanesan, Ratan K Banik, Hariharan Shankar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuromodulation : journal of the International Neuromodulation Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 2 countries.

Vasudha GoelDepartment of Anesthesiology, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0001-9311-1399
Varun KumarDepartment of Neurology, University of South Florida, Tampa, FL, USA.
Shivani N AgrawalAmerican University of Integrative Sciences, Cole Bay, Sint Maarten.
Amol M PatwardhanDepartment of Anesthesiology, University of Arizona, Tucson, AZ, USA.
Mohab IbrahimDepartment of Anesthesiology, University of Arizona, Tucson, AZ, USA.
Daniel C DeSimoneInfectious Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Eellan SivanesanDepartment of Anesthesiology, Johns Hopkins University, Baltimore, MD, USA.
Ratan K BanikDepartment of Anesthesiology, University of Minnesota, Minneapolis, MN, USA.
Hariharan ShankarDepartment of Anesthesiology, Clement Zablocki VA Medical Center, Medical College of Wisconsin, Milwaukee, WI, USA.
University of Arizona · USUniversity of Minnesota · USAmerican University of Integrative Sciences · SXJohns Hopkins University · USMayo Clinic · USMedical College of Wisconsin · USUniversity of South Florida · US

Funding

Validation of Spinal Neurotensin Receptor 2 as an Analgesic TargetR01NS116694 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PATWARDHAN, AMOL M · 2020 to 2025
$2.0M
Mechanism of intrathecal Contulakin-G induced analgesia without motor blockK08NS104272 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PATWARDHAN, AMOL M · 2018 to 2022
$987k
NINDS NIH HHS K08 NS104272NINDS NIH HHS R01 NS116694
6 · The paper itself

Abstract

objectivesChronic pain spinal implantable electronic devices (CPSIEDs) include devices that provide spinal cord stimulation and intrathecal drug therapy. In this study, we sought to evaluate the trends of CPSIED infections, related complications, and outcomes following the treatment of infection. MATERIALS AND

methodsThe Nationwide Inpatient Sample database contains data from 48 states, and the District of Columbia was used to identify patients with a primary diagnosis of CPSIED infection during the years 2005-2014. Patients with intrathecal pumps for the treatment of spasticity were excluded to limit the study population to patients with chronic pain disorders. Treatments were categorized as: 1) without device removal, 2) pulse generator or pump only removal, 3) intrathecal pump system removal, and 4) spinal cord stimulation system removal. Complications associated with CPSIED infections were identified using administrative billing codes.

resultsDuring the study period 2005-2014, a total of 11,041 patients were admitted to the hospital with CPSIED infections. The majority of the patients were treated without surgical intervention (56%), and a smaller proportion underwent complete system explantation (22.7%). In-hospital mortality or permanent disability due to paralysis after CPSIED infection was around 1.83% and 2.77%, respectively. Infectious complications such as meningitis, abscess formation, and osteomyelitis occurred in 4.93%, 5.08%, and 1.5%, respectively. The median cost of hospitalization was around US $14,118.00, and the median length of stay was approximately six days (interquartile range = 4-13 days).

conclusionsThe complications of CPSIED infection were higher among patients that did not undergo device removal.

Indexed as

Chronic PainSpinal Cord StimulationElectronicsHumansInfusion Pumps, ImplantableInpatientsMuscle SpasticityIntrathecal pump infectionsoutcomesspinal cord stimulator infections

Identifiers

PMID32929856
PMCPMC9076045
OpenAlexW3087598260

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.