Evidence map›Paper›PMID 32929770›Full record

ArticleMagnetic resonance in medicine2021

Quantifying the effect of dobutamine stress on myocardial Pi and pH in healthy volunteers: A

Andrew Apps, Ladislav Valkovič, Mark Peterzan, Justin Y C Lau, Moritz Hundertmark, William Clarke, Elizabeth M Tunnicliffe, Jane Ellis, Damian J Tyler, Stefan Neubauer and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. NMR in biomedicine · 2026
    Article
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  6. CardiacHeart failure reviews · 2023
    Review
  7. Assessment of sodium (Polish journal of radiology · 2023
    Article
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  9. Review
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  11. Article
  12. Ischemia-Reperfusion Injuries Assessment during Pancreas Preservation.International journal of molecular sciences · 2021
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Andrew AppsOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-0478-8918
Ladislav ValkovičOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-2567-3642
Mark PeterzanOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Justin Y C LauOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-7316-811X
Moritz HundertmarkOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
William ClarkeOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-7159-7025
Elizabeth M TunnicliffeOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Jane EllisOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Damian J TylerOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Stefan NeubauerOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Oliver J RiderOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Christopher T RodgersOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-1275-1197
Albrecht Ingo SchmidOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-5196-151X
John Radcliffe Hospital · GBSlovak Academy of Sciences · SKUniversity of Cambridge · GB

Funding

British Heart Foundation FS/14/17/30634British Heart Foundation FS/14/17/30635British Heart Foundation FS/15/80/31803British Heart Foundation FS/17/18/32449British Heart Foundation FS/19/18/34252Department of HealthWellcome TrustWellcome Trust 098436/Z/12/B
6 · The paper itself

Abstract

purposePhosphorus spectroscopy (

methodsUsing a

resultsWe achieved a clean Pi signal both at rest and stress with good 2,3-DPG suppression. Repeatability coefficient (8 subjects) for Pi/PCr was 0.036 and 0.12 for pH. We report myocardial Pi/PCr and pH at rest and during catecholamine stress in healthy controls. Pi/PCr was maintained during stress (0.098 ± 0.031 [rest] vs. 0.098 ± 0.031 [stress] P = .95); similarly, pH did not change (7.09 ± 0.07 [rest] vs. 7.08 ± 0.11 [stress] P = .81). Feasibility for patient studies was subsequently successfully demonstrated in a patient with cardiomyopathy.

conclusionWe introduced a method that can resolve Pi using 7 Tesla STEAM

Indexed as

DobutamineMyocardiumAdenosine TriphosphateHumansHydrogen-Ion ConcentrationMagnetic Resonance SpectroscopyPhosphatesPhosphocreatineAdenosine TriphosphateDobutaminePhosphatesPhosphocreatine31P MRS7Tcardiac energeticsmyocardial pHSTEAM

Identifiers

PMID32929770
PMCPMC8239988
OpenAlexW3087153990

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.