Evidence map›Paper›PMID 32929743›Full record

ArticleGenetic epidemiology2021

locStra: Fast analysis of regional/global stratification in whole-genome sequencing studies.

Georg Hahn, Sharon M Lutz, Julian Hecker, Dmitry Prokopenko, Michael H Cho, Edwin K Silverman, Scott T Weiss, Christoph Lange, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

Abstract read
In one paragraph

Article in Genetic epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Georg HahnDepartment of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.ORCID 0000-0001-6008-2720
Sharon M LutzDepartment of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Julian HeckerDepartment of Medicine, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts, USA.ORCID 0000-0001-7918-089X
Dmitry ProkopenkoMassachusetts General Hospital, Harvard University, Boston, Massachusetts, USA.
Michael H ChoDepartment of Medicine, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts, USA.
Edwin K SilvermanDepartment of Medicine, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts, USA.
Scott T WeissDepartment of Medicine, Brigham and Women's Hospital, Harvard University, Boston, Massachusetts, USA.
Christoph LangeDepartment of Biostatistics, T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Finding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6M
Systems Biology of Airway DiseaseP01HL132825 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DEMEO, DAWN L · 2016 to 2020
$12.6M
Physics of collective cellular migration in lung health and diseaseP01HL120839 · NHLBI · HARVARD SCHOOL OF PUBLIC HEALTH · PI FREDBERG, JEFFREY J · 2014 to 2018
$12.2M
Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Preparing Association Analysis Software Tools for Next Generation Sequencing DataR01HG008976 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI LANGE, CHRISTOPH · 2016 to 2018
$1.1M
NHGRI NIH HHS R01 HG008976NHGRI NIH HHS U01 HG008685NHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS P01 HL120839NHLBI NIH HHS P01 HL132825NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897NHLBI NIH HHS U01 HL120393
6 · The paper itself

Abstract

locStra is an

Indexed as

GenomeGenome-Wide Association StudyAlgorithmsGenomicsHumansPolymorphism, Single NucleotideWhole Genome Sequencingpopulation stratificationpopulation substructureregional analysissimilarity matrixwhole-genome sequencing

Identifiers

PMID32929743
PMCPMC7856019

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.