Evidence map›Paper›PMID 32929605›Full record

ReviewStem cell reviews and reports2020

Human Female Reproductive System Organoids: Applications in Developmental Biology, Disease Modelling, and Drug Discovery.

Yutong Cui, Huanqiang Zhao, Suwen Wu, Xiaotian Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Stem cell reviews and reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Nature does it better: mimickingFrontiers in veterinary science · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Bioengineering Approaches for Placental Research.Annals of biomedical engineering · 2021
    Review
  16. Building a stem cell-based primate uterus.Communications biology · 2021
    Review
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yutong CuiObstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.
Huanqiang ZhaoObstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.
Suwen WuObstetrics and Gynaecology Hospital of Fudan University, Shanghai, China.
Xiaotian LiObstetrics and Gynaecology Hospital of Fudan University, Shanghai, China. xiaotianli555@163.com.ORCID 0000-0002-5929-5101

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organoid technique has achieved significant progress in recent years, owing to the rapid development of the three-dimensional (3D) culture techniques in adult stem cells (ASCs) and pluripotent stem cells (PSCs) that are capable of self-renewal and induced differentiation. However, our understanding of human female reproductive system organoids is in its infancy. Recently, scientists have established self-organizing 3D organoids for human endometrium, fallopian tubes, oocyte, and trophoblasts by culturing stem cells with a cocktail of cytokines in a 3D scaffold. These organoids express multicellular biomarkers and show functional characteristics similar to those of their origin organs, which provide potential avenues to explore reproductive system development, disease modelling, and patient-specific therapy. Nevertheless, advanced culture methods, such as co-culture system, 3D bioprinting and organoid-on-a-chip technology, remain to be explored, and more efforts should be made for further elucidation of cell-cell crosstalk. This review describes the development and applications of human female reproductive system organoids. Graphical abstract Figure: Applications in developmental biology, disease modelling, and drug discovery of human female reproductive system organoids. ASCs: adult stem cells; PSCs: pluripotent stem cells.

Indexed as

Developmental BiologyDrug DiscoveryAnimalsDisease Models, AnimalFemaleGenitalia, FemaleHumansOrganoidsTrophoblasts3D remodelingDisease modellingEndometriumFallopian tubeFollicleOrganoidsStem cellTrophoblast

Identifiers

PMID32929605

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.