Evidence map›Paper›PMID 32929559›Full record

ArticleAnnals of biomedical engineering2020

Physical, Biomechanical, and Optical Characterization of Collagen and Elastin Blend Hydrogels.

Nelda Vazquez-Portalatin, Alba Alfonso-Garcia, Julie C Liu, Laura Marcu, Alyssa Panitch

Open access · greenAbstract read
In one paragraph

Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

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  14. Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nelda Vazquez-PortalatinBiomedical Engineering Department, University of California, Davis, 451 Health Sciences Dr, Davis, CA, 95616, USA.
Alba Alfonso-GarciaBiomedical Engineering Department, University of California, Davis, 451 Health Sciences Dr, Davis, CA, 95616, USA.
Julie C LiuWeldon School of Biomedical Engineering, Purdue University, 206 S Martin Jischke Dr, West Lafayette, IN, 47907, USA.
Laura MarcuBiomedical Engineering Department, University of California, Davis, 451 Health Sciences Dr, Davis, CA, 95616, USA.
Alyssa PanitchBiomedical Engineering Department, University of California, Davis, 451 Health Sciences Dr, Davis, CA, 95616, USA. apanitch@ucdavis.edu.ORCID http://orcid.org/0000-0002-0360-1480
University of California, Davis · USPurdue University West Lafayette · US

Funding

Bimodal platform for nondestructive analysis of engineered vascular biomaterialsR01HL121068 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GRIFFITHS, LEIGH GARETH, MARCU, LAURA · 2015 to 2018
$1.5M
Investigation of Proteoglycan Mimetics as Treatments for OsteoarthritisR01AR065398 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PANITCH, ALYSSA · 2014 to 2018
$1.4M
NHLBI NIH HHS R01 HL121068NIAMS NIH HHS R01 AR065398
6 · The paper itself

Abstract

Collagen and elastin proteins are major components of the extracellular matrix of many organs. The presence of collagen and elastin networks, and their associated properties, in different tissues have led scientists to study collagen and elastin composites for use in tissue engineering. In this study, we characterized physical, biochemical, and optical properties of gels composed of collagen and elastin blends. We demonstrated that the addition of varying amounts of elastin to the constructs alters collagen fibrillogenesis, D-banding pattern length, and storage modulus. However, the addition of elastin does not affect collagen fibril diameter. We also evaluated the autofluorescence properties of the different collagen and elastin blends with fluorescence lifetime imaging (FLIm). Autofluorescence emission showed a red shift with the addition of elastin to the hydrogels. The fluorescence lifetime values of the gels increased with the addition of elastin and were strongly correlated with the storage moduli measurements. These results suggest that FLIm can be used to monitor the gels' mechanical properties nondestructively. These collagen and elastin constructs, along with the FLIm capabilities, can be used to develop and study collagen and elastin composites for tissue engineering and regenerative medicine.

Indexed as

Collagen Type IElastinHydrogelsBiomechanical PhenomenaMicroscopy, Electron, TransmissionOptical ImagingPhysical PhenomenaRheologyCollagen Type IElastinHydrogelsAutofluorescence lifetimeD-banding patternFibrillogenesisFLImStorage modulus

Identifiers

PMID32929559
PMCPMC7770626
OpenAlexW3085619348

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.