Evidence map›Paper›PMID 32929521›Full record

ArticleHNO2021

[Functional outcome after transmandibular resection and primary chemoradiation in advanced oropharyngeal squamous cell carcinoma].

A Knopf, N Mansour, B Hofauer, F Johnson, H Bier, F Wakonig, S Teutsch

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HNO, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

A KnopfKlinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, Klinikum rechts der Isar der Technischen Universität München, Killianstraße 5, 79106, München, Deutschland. andreas.knopf@uniklinik-freiburg.de.
N MansourKlinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, Klinikum rechts der Isar der Technischen Universität München, Killianstraße 5, 79106, München, Deutschland.
B HofauerKlinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, Klinikum rechts der Isar der Technischen Universität München, Killianstraße 5, 79106, München, Deutschland.
F JohnsonKlinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, Klinikum rechts der Isar der Technischen Universität München, Killianstraße 5, 79106, München, Deutschland.
H BierKlinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, Klinikum rechts der Isar der Technischen Universität München, Killianstraße 5, 79106, München, Deutschland.
F WakonigKlinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, Klinikum rechts der Isar der Technischen Universität München, Killianstraße 5, 79106, München, Deutschland.
S TeutschKlinik und Poliklinik für Hals‑, Nasen- und Ohrenheilkunde, Klinikum rechts der Isar der Technischen Universität München, Killianstraße 5, 79106, München, Deutschland.
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde · DEKlinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde · DEKlinikum rechts der Isar · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this study was to assess the functional outcome after transmandibular resection and reconstruction via a radial forearm flap (TMR+RFF) compared to primary chemoradiotherapy (pCRT) in advanced oropharyngeal squamous cell carcinoma (OPSCC).

methodsThe study compared 50 OPSCC patients treated with TMR+RFF to 50 OPSCC patients receiving pCRT. The time taken to swallow water served as the primary endpoint. The Saxon test, maxillomandibular distance, Mallampati score, ratio of height to weight, nasal penetration, tracheostomy/gastral tube requirement, and four validated questionnaires (visual analog scale for xerostomia, Sicca VAS; MD Anderson Dysphagia Inventory, MDADI; Voice Handicap Index, VHI; European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Head and Neck Cancer, 35 items, QLQ-H&N35) were applied to access functionality and quality of life.

resultsPatients after TMR+RFF showed an increased rate of nasal penetration (p < 0.0001), which was associated with a longer water swallowing time (p < 0.05). A modified reconstruction of the soft palate significantly decreased the rate of nasal penetration in comparison to classical reconstruction (p = 0.0001). Patients with pCRT suffered significantly more xerostomia (Saxon test) than patients with TMR+RFF and adjuvant therapy. None of the subjective questionnaires revealed significant differences between the groups.

conclusionTMR+RFF with modified reconstruction and adjuvant treatment and pCRT showed comparable functional outcomes.

Indexed as

Deglutition DisordersHead and Neck NeoplasmsOropharyngeal NeoplasmsChemoradiotherapyDeglutitionHumansQuality of LifeSquamous Cell Carcinoma of Head and NeckHead neck neoplasmsQuality improvementQuality of health careQuality of lifeSurgical oncology

Identifiers

PMID32929521
PMCPMC7862514
OpenAlexW3085775309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.