ArticleThe Journal of clinical endocrinology and metabolism2020
Hip Structural Analysis Reveals Impaired Hip Geometry in Girls With Type 1 Diabetes.
Article in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Cardiorespiratory Fitness and Physical Activity in Pediatric Diabetes: A Systemic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Trabecular bone score in adults with type 1 diabetes: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Pooled it
- Causal relationship between Type 1 diabetes and osteoporosis and fracture occurrence: a two-sample Mendelian randomization analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Pooled it
- Higher Body Fat in Children and Adolescents With Type 1 Diabetes-A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2022Pooled it
- Bone Mineral Density and Type 1 Diabetes in Children and Adolescents: A Meta-analysis.Diabetes care · 2021Pooled it
- A clinically applicable energy-based approach for evaluating bone strength.Bone & joint research · 2026Article
- Adolescent Girls With Type 1 Diabetes Develop Changes in Bone Prior to Evidence of Clinical Neuropathy.The Journal of clinical endocrinology and metabolism · 2025Article
- Collagen glycosylation, hip structural analysis, and trabecular bone score in adolescents with type 1 diabetes: a cross-sectional study.Diabetology & metabolic syndrome · 2025Article
- Article
- Total Calcium Intake Is Associated With Trabecular Bone Density in Adolescent Girls With Type 1 Diabetes.JBMR plus · 2023Article
- Glycemic Control and Bone in Diabetes.Current osteoporosis reports · 2022Review
- Femoral neck structural properties are altered in adults with type 1 diabetes.Journal of diabetes and its complications · 2022Article
- An update on methods for assessing bone quality and health in Cystic fibrosis.Journal of clinical & translational endocrinology · 2022Article
- Retrospective Analysis of Factors Associated with Fracture in 714 Patients with Polymyalgia Rheumatica.International journal of rheumatology · 2022Article
- Hip Structural Analysis Reveals Impaired Hip Geometry in Girls With Type 1 Diabetes.The Journal of clinical endocrinology and metabolism · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
contextAmong patients with type 1 diabetes (T1D), the risk of hip fracture is up to 6-fold greater than that of the general population. However, the cause of this skeletal fragility remains poorly understood.
objectiveTo assess differences in hip geometry and imaging-based estimates of bone strength between youth with and without T1D using dual-energy x-ray absorptiometry (DXA)-based hip structural analysis.
designCross-sectional comparison.
participantsGirls ages 10 to 16 years, including n = 62 with T1D and n = 61 controls.
resultsThe groups had similar age, bone age, pubertal stage, height, lean mass, and physical activity. Bone mineral density at the femoral neck and total hip did not differ in univariate comparisons but was lower at the femoral neck in T1D after adjusting for bone age, height, and lean mass. Subjects with T1D had significantly lower cross-sectional area, cross-sectional moment of inertia, section modulus, and cortical thickness at the narrow neck, with deficits of 5.7% to 10.3%. Cross-sectional area was also lower at the intertrochanteric region in girls with T1D. Among those T1D subjects with HbA1c greater than the cohort median of 8.5%, deficits in hip geometry and strength estimates were more pronounced.
conclusionsDXA-based hip structural analysis revealed that girls with T1D have unfavorable geometry and lower estimates of bone strength at the hip, which may contribute to skeletal fragility and excess hip fracture risk in adulthood. Higher average glycemia may exacerbate effects of T1D on hip geometry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.