Evidence map›Paper›PMID 32929363›Full record

ArticleTheranostics2020

Broaden sources and reduce expenditure: Tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy.

Xiaoyu Xu, Binyao Huang, Zishan Zeng, Jie Chen, Zeqian Huang, Zilin Guan, Meixu Chen, Yanjuan Huang, Chunshun Zhao

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiaoyu XuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Binyao HuangSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Zishan ZengSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Jie ChenSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Zeqian HuangSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Zilin GuanSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Meixu ChenSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Yanjuan HuangSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Chunshun ZhaoSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, P. R. China.
Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer cells immersed in inherent oxidative stress are more vulnerable to exogenous oxidative damages than normal cells. Reactive oxygen species (ROS)-mediated oxidation therapy preferentially aggravating tumor oxidative stress to disrupt redox homeostasis, has emerged as an effective and specific anticancer treatment. Herein, following an ingenious strategy of "broaden sources and reduce expenditure", we designed a versatile tumor-specific oxidative stress nanoamplifier enabling economized photodynamic therapy (PDT), to achieve synergistic oxidative stress explosion for superior oxidation therapy.

Indexed as

AcroleinAnimalsAntineoplastic AgentsBiological AvailabilityCell Line, TumorCell SurvivalDisease Models, AnimalDrug CarriersDrug CompoundingDrug SynergismFemaleHumansHyaluronic AcidMiceNanospheresNeoplasmsAcroleinAntineoplastic AgentscinnamaldehydeDrug CarriersHyaluronic AcidPhotosensitizing Agentsprotoporphyrin IXProtoporphyrinsReactive Oxygen Speciesbroaden sources and reduce expenditureeconomized photodynamic therapyoxidation therapyOxidative stressreactive oxygen species

Identifiers

PMID32929363
PMCPMC7482813
OpenAlexW3082886885

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.