Evidence map›Paper›PMID 32929330›Full record

ArticleTheranostics2020

Dysregulated Kras/YY1/ZNF322A/Shh transcriptional axis enhances neo-angiogenesis to promote lung cancer progression.

Che-Chung Lin, I-Ying Kuo, Li-Ting Wu, Wen-Hui Kuan, Sheng-You Liao, Jayu Jen, You-En Yang, Cheng-Wei Tang, Yi-Rong Chen, Yi-Ching Wang

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 49 citations in OpenAlex.

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  9. Impact of KRAS mutation on the tumor microenvironment in colorectal cancer.International journal of biological sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Che-Chung LinDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
I-Ying KuoDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Li-Ting WuDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Wen-Hui KuanDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Sheng-You LiaoInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Jayu JenInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
You-En YangDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Cheng-Wei TangDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Yi-Rong ChenInstitute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, 35053, Taiwan.
Yi-Ching WangDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
National Cheng Kung University · TWNational Health Research Institutes · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Angiogenesis enhances cancer metastasis and progression, however, the roles of transcription regulation in angiogenesis are not fully defined. ZNF322A is an oncogenic zinc-finger transcription factor. Here, we demonstrate a new mechanism of

Indexed as

AnimalsCell Line, TumorCell MovementCell ProliferationDisease ProgressionEndothelial CellsHedgehog ProteinsHumansHuman Umbilical Vein Endothelial CellsLungLung NeoplasmsMice, Inbred C57BLMice, TransgenicNeovascularization, PathologicOncogene ProteinsOncogenesHedgehog ProteinsKRAS protein, humanOncogene ProteinsProto-Oncogene Proteins p21(ras)SHH protein, humanTranscription FactorsYY1 protein, humanYY1 Transcription FactorZNF322 protein, humanangiogenesisKrasLung cancerShhtranscription

Identifiers

PMID32929330
PMCPMC7481419
OpenAlexW3082095690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.