ArticleNature genetics2020
Complex genetic signatures in immune cells underlie autoimmunity and inform therapy.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 801 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
801citing papers in PubMed, 2 pooled it
8.3field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
801 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,192 citations in OpenAlex.
- Bidirectional Mendelian Randomization and Colocalization Study of Memory B Cells and Major Depressive Disorder.Current medical science · 2026Pooled it
- Mendelian randomization identifies multiple immune cell surface markers as potential causal contributors and drug targets in rheumatoid arthritis.The Journal of international medical research · 2026Pooled it
- Causal relationships between the gut microbiota, immune cells, and diabetic kidney disease: a Mendelian randomization and mediation analysis.Renal failure · 2026Article
- Mass-Spectrometry-Identified Quality Markers of Jingtong Granules Are Predicted to Engage Upregulated Neutrophil Granule Enzymes in Cervical Spondylotic Radiculopathy: An Integrative Machine-Learning and Molecular-Dynamics Study.Rapid communications in mass spectrometry : RCM · 2026Article
- GLP-1R expression and dermatological diseases: a mendelian randomization and real-world study.Endocrine · 2026Article
- Targeting the CD4Molecular biomedicine · 2026Article
- The causal relationship between immune cells, white matter microstructure and dementia: a Mendelian randomization study and co-localization analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Integrated multi-omics and functional analyses reveal a GDCA-TGR5-mediated immunometabolic signature in anorexia nervosa.European archives of psychiatry and clinical neuroscience · 2026Article
- Circulating asparagine and short stature: A case-control study and exploratory two-sample Mendelian randomization analysis.Medicine · 2026Article
- Mendelian randomization analysis reveals causal links between specific immune cell phenotypes and Parkinson's disease.Clinics (Sao Paulo, Brazil) · 2026Article
- Genetic Evidence for a Putative B Cell-Cholate Immunometabolic Axis in Pericarditis: A Mendelian Randomization Study.Biomedicines · 2026Article
- Cerebrospinal Fluid Metabolites Mediate Immune Cell Effects on Chronic Pain.Molecular neurobiology · 2026Article
- The role of ferroptosis in juvenile idiopathic arthritis: Causal inference and mediation by immune phenotypes.Medicine · 2026Article
- Causal relationship between immune factors and Guillain-Barré syndrome: A Mendelian randomization study.Medicine · 2026Article
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- Integrative genomic and proteomic analyses identify candidate genetic loci and genetically supported proteins in age-related macular degeneration.Eye and vision (London, England) · 2026Article
- DSG2 Expression Marks a Stromal-Immune Organizational State in Head and Neck Squamous Cell Carcinoma.Cancers · 2026Article
- ZDHHC5 may regulate the function of NKT cells and the immune response in Meniere's disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns.American journal of human genetics · 2026Article
741 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
28 authors at 6 institutions in 3 countries.
Valeria Orrù *Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.ORCID http://orcid.org/0000-0002-6047-4625
Maristella Steri *Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.ORCID http://orcid.org/0000-0001-5869-3872
Carlo Sidore *Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.ORCID http://orcid.org/0000-0001-7504-7477
Michele MarongiuIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.ORCID http://orcid.org/0000-0002-7289-9815
Valentina SerraIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Stefania OllaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Gabriella SoleIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Sandra LaiIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Mariano DeiIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Antonella MulasIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Francesca VirdisIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Maria Grazia PirasIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Monia LobinaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.ORCID http://orcid.org/0000-0003-3620-3160
Mara MarongiuIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Maristella PitzalisIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Francesca DeiddaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Annalisa LoizeddaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Stefano OnanoIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Magdalena ZoledziewskaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Stephen SawcerDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Marcella DevotoDivision of Genetics, The Children's Hospital of Philadelphia, and Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA.
Myriam GorospeLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Gonçalo R AbecasisCenter for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-1509-1825
Matteo FlorisIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.ORCID http://orcid.org/0000-0003-4385-9336
Mauro PalaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
David SchlessingerLaboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Edoardo FiorilloIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy. fcucca@uniss.it.ORCID http://orcid.org/0000-0002-7414-1995
Institute of Genetic and Biomedical Research · ITUniversity of Sassari · ITNational Institutes of Health · USChildren's Hospital of Philadelphia · USUniversity of Cambridge · GBUniversity of Michigan · US
Funding
Aging-related Traits and Disease Risk Factors in a Sardinian Population CohortZ01AG000675 · NIA · NATIONAL INSTITUTE ON AGING · PI SCHLESSINGER, DAVID · 2007 to 2008
$751kIntramural NIH HHS Z01 AG000675NIDA NIH HHS HHSN271201600005CNIDA NIH HHS HHSN271201600005I
Abstract
We report on the influence of ~22 million variants on 731 immune cell traits in a cohort of 3,757 Sardinians. We detected 122 significant (P < 1.28 × 10
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyAutoimmune DiseasesAutoimmunityHumansItalyPhenotypePolymorphism, Single Nucleotide
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