Evidence map›Paper›PMID 32929265›Full record

ArticleNature medicine2020

Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: a phase I, multicenter, open-label, dose-escalation study.

Adrian J C Bloor, Amit Patel, James E Griffin, Maria H Gilleece, Rohini Radia, David T Yeung, Diana Drier, Laurie S Larson, Gene I Uenishi, Derek Hei and 3 more

Abstract readClinical Trial, Phase IMulticenter Study
PubMed Publisher
In one paragraph

Article in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 178 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
178citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

178 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Baseline CD4Journal of blood medicine · 2025
    Trial
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

118 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adrian J C BloorHaematology & Transplant Unit, The Christie NHS Foundation Trust, Manchester, UK. adrian.bloor@christie.nhs.uk.ORCID http://orcid.org/0000-0003-4550-220X
Amit PatelHaematology & Transplant Unit, The Christie NHS Foundation Trust, Manchester, UK.ORCID http://orcid.org/0000-0003-0029-4611
James E GriffinDepartment of Bone Marrow Transplantation, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
Maria H GilleeceDepartment of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.ORCID http://orcid.org/0000-0003-0364-3573
Rohini RadiaDepartment of Haematology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
David T YeungSchool of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Diana DrierWaisman Biomanufacturing, University of Wisconsin-Madison, Madison, WI, USA.
Laurie S LarsonWaisman Biomanufacturing, University of Wisconsin-Madison, Madison, WI, USA.
Gene I UenishiDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, USA.
Derek HeiBlueRock Therapeutics, Cambridge, MA, USA.
Kilian KellyCynata Therapeutics Limited, Carlton, Victoria, Australia.ORCID http://orcid.org/0000-0002-1666-1896
Igor SlukvinDepartment of Cell and Regenerative Biology, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-9693-6927
John E J RaskoDepartment of Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia. j.rasko@centenary.org.au.ORCID http://orcid.org/0000-0003-3181-7198

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The therapeutic potential of donor-derived mesenchymal stromal cells (MSCs) has been investigated in diverse diseases

Indexed as

Mesenchymal Stem Cell TransplantationAdolescentAdultAgedDrug ResistanceFemaleGraft vs Host DiseaseHumansInduced Pluripotent Stem CellsMaleMiddle AgedRemission InductionSteroidsSurvival RateYoung AdultSteroids

Identifiers

PMID32929265

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.