Evidence map›Paper›PMID 32929262›Full record

ReviewNature reviews. Neuroscience2020

Emergence of abstract rules in the primate brain.

Farshad Alizadeh Mansouri, David J Freedman, Mark J Buckley

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Prefrontal Mechanisms of Rule Learning.bioRxiv : the preprint server for biology · 2026
    Article
  11. Neural representation of action symbols in primate frontal cortex.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Cognitive Maps in the Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Bridging Species Differences in Rule Switching: How Humans and Monkeys Solve the Same Wisconsin Card Sorting Task.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Farshad Alizadeh MansouriBiomedicine Discovery Institute and Department of Physiology, Monash University, Clayton, VIC, Australia. farshad.mansouri@monash.edu.ORCID http://orcid.org/0000-0001-9130-1789
David J FreedmanDepartment of Neurobiology, The University of Chicago, Chicago, IL, USA.
Mark J BuckleyDepartment of Experimental Psychology, The University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7455-8486

Funding

Medical Research Council MR/K005480/1
6 · The paper itself

Abstract

Various aspects of human cognition are shaped and enriched by abstract rules, which help to describe, link and classify discrete events and experiences into meaningful concepts. However, where and how these entities emerge in the primate brain and the neuronal mechanisms underlying them remain the subject of extensive research and debate. Evidence from imaging studies in humans and single-neuron recordings in monkeys suggests a pivotal role for the prefrontal cortex in the representation of abstract rules; however, behavioural studies in lesioned monkeys and data from neuropsychological examinations of patients with prefrontal damage indicate substantial functional dissociations and task dependency in the contribution of prefrontal cortical regions to rule-guided behaviour. This Review describes our current understanding of the dynamic emergence of abstract rules in primate cognition, and of the distributed neural network that supports abstract rule formation, maintenance, revision and task-dependent implementation.

Indexed as

AnimalsBrainCuesDecision MakingExecutive FunctionHumansLearningMemoryNeural PathwaysNeuronsNeuropsychological TestsPrimates

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.