ArticleNature neuroscience2020
Dense neuronal reconstruction through X-ray holographic nano-tomography.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed.
- Phase and absorbance retrieval in X-ray holographic microscopy under weak illumination using physics-driven neural networks.Journal of synchrotron radiation · 2026Article
- Critical point drying of brain tissue for X-ray phase-contrast imaging.Journal of synchrotron radiation · 2026Article
- Radiation-dose effects in correlative X-ray/cryo-electron microscopy of frozen-hydrated biological samples.Acta crystallographica. Section D, Structural biology · 2026Article
- 3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x-ray phase-contrast tomography.Brain pathology (Zurich, Switzerland) · 2026Article
- A multi-resolution imaging and analysis pipeline for comparative circuit reconstruction in insects.bioRxiv : the preprint server for biology · 2026Article
- Proprioceptive limit detectors contribute to sensorimotor control of the Drosophila leg.Nature communications · 2026Article
- A neural connectivity atlas for fly flight control.Current biology : CB · 2026Article
- High-Resolution Single-Neuron Reconstruction Analysis in Golgi-Stained Brain Tissues.Cell proliferation · 2026Article
- Synaptic-resolution connectomics: towards large brains and connectomic screening.Nature reviews. Neuroscience · 2026Review
- Reconstructing the human brain's wiring diagram from axons up.Trends in neurosciences · 2026Review
- Article
- A lung CT vision foundation model facilitating disease diagnosis and medical imaging.Nature communications · 2025Article
- Connectomics beyond electron microscopy.Nature methods · 2025Article
- Nondestructive X-ray tomography of brain tissue ultrastructure.Nature methods · 2025Article
- Unlocking the potential of X-rays to scale up tissue ultrastructure mapping.Nature methods · 2025Article
- Cryo-CLXEM introduces cryo-SXT to bridge the resolution gap in cryo-CLEM.Communications biology · 2025Article
- Article
- 3D histology of human heart-forming organoids by X-ray phase-contrast tomography.Communications biology · 2025Article
- Three-photon microscopy: an emerging technique for deep intravital brain imaging.Nature reviews. Neuroscience · 2025Review
- Near-Freezing-Temperature Golgi Neuronal Staining for X-ray Imaging of Human Brain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
23 more citing papers are in PubMed but not listed here.
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12 authors.
Funding
Abstract
Imaging neuronal networks provides a foundation for understanding the nervous system, but resolving dense nanometer-scale structures over large volumes remains challenging for light microscopy (LM) and electron microscopy (EM). Here we show that X-ray holographic nano-tomography (XNH) can image millimeter-scale volumes with sub-100-nm resolution, enabling reconstruction of dense wiring in Drosophila melanogaster and mouse nervous tissue. We performed correlative XNH and EM to reconstruct hundreds of cortical pyramidal cells and show that more superficial cells receive stronger synaptic inhibition on their apical dendrites. By combining multiple XNH scans, we imaged an adult Drosophila leg with sufficient resolution to comprehensively catalog mechanosensory neurons and trace individual motor axons from muscles to the central nervous system. To accelerate neuronal reconstructions, we trained a convolutional neural network to automatically segment neurons from XNH volumes. Thus, XNH bridges a key gap between LM and EM, providing a new avenue for neural circuit discovery.
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