Evidence map›Paper›PMID 32929076›Full record

ArticleCell death & disease2020

Activation of Wnt signaling by amniotic fluid stem cell-derived extracellular vesicles attenuates intestinal injury in experimental necrotizing enterocolitis.

Bo Li, Carol Lee, Joshua S O'Connell, Lina Antounians, Niloofar Ganji, Mashriq Alganabi, Marissa Cadete, Francesca Nascimben, Yuhki Koike, Alison Hock and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 60 citations in OpenAlex.

  1. Pooled it
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  7. Amniotic fluid: its role in fetal development and beyond.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 4 institutions in 2 countries.

Bo LiTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.ORCID http://orcid.org/0000-0002-8298-8344
Carol LeeTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Joshua S O'ConnellTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Lina AntouniansDivision of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Niloofar GanjiTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Mashriq AlganabiTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Marissa CadeteTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Francesca NascimbenTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Yuhki KoikeTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Alison HockTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Steven R BottsCell Biology Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Richard Y WuCell Biology Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Hiromu MiyakeTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Adam MinichTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Michael F MaaloufTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.ORCID http://orcid.org/0000-0001-9035-9487
Elke Zani-RuttenstockTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Yong ChenTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Kathene C Johnson-HenryCell Biology Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.ORCID http://orcid.org/0000-0002-6046-550X
Paolo De CoppiUCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.
Simon EatonUCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.ORCID http://orcid.org/0000-0003-0892-9204
Pekka MaattanenBiology Department, Burman University, Lacombe, AB, T4L 2E5, Canada.
Paul Delgado OlguinTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.ORCID http://orcid.org/0000-0002-5355-247X
Augusto ZaniDivision of General and Thoracic Surgery, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Philip M ShermanCell Biology Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
Agostino PierroTranslational Medicine Program, The Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada. agostino.pierro@sickkids.ca.ORCID http://orcid.org/0000-0002-6742-6570
Hospital for Sick Children · CAUniversity of Toronto · CAGreat Ormond Street Hospital · GBBurman University · CA

Funding

CIHR IOP-92890CIHR MOP-89894Medical Research Council MR/N028414/1
6 · The paper itself

Abstract

Necrotizing enterocolitis (NEC) is a devastating intestinal disease primarily affecting preterm neonates and causing high morbidity, high mortality, and huge costs for the family and society. The treatment and the outcome of the disease have not changed in recent decades. Emerging evidence has shown that stimulating the Wnt/β-catenin pathway and enhancing intestinal regeneration are beneficial in experimental NEC, and that they could potentially be used as a novel treatment. Amniotic fluid stem cells (AFSC) and AFSC-derived extracellular vesicles (EV) can be used to improve intestinal injury in experimental NEC. However, the mechanisms by which they affect the Wnt/β-catenin pathway and intestinal regeneration are unknown. In our current study, we demonstrated that AFSC and EV attenuate NEC intestinal injury by activating the Wnt signaling pathway. AFSC and EV stimulate intestinal recovery from NEC by increasing cellular proliferation, reducing inflammation and ultimately regenerating a normal intestinal epithelium. EV administration has a rescuing effect on intestinal injury when given during NEC induction; however, it failed to prevent injury when given prior to NEC induction. AFSC-derived EV administration is thus a potential emergent novel treatment strategy for NEC.

Indexed as

AnimalsDisease Models, AnimalEnterocolitis, NecrotizingExtracellular VesiclesHumansIntestinesMiceRatsWnt Signaling Pathway

Identifiers

PMID32929076
PMCPMC7490270
OpenAlexW3085393855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.