ArticleNature communications2020
Prior knowledge promotes hippocampal separation but cortical assimilation in the left inferior frontal gyrus.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Trial
- The human hippocampus can pattern separate memories by meaning.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The effects of hippocampal dentate gyrus lesions on categorical face perception.Attention, perception & psychophysics · 2026Article
- Hippocampal formation-cortical high-fidelity memory networks in healthy older adults during the mnemonic discrimination task.Frontiers in aging neuroscience · 2026Article
- Neuronal mismatch responses to auditory stimuli in the dorsal hippocampus of anesthetized rats.Communications biology · 2025Article
- Complementary roles of the human perirhinal and the entorhinal cortex in the hippocampal retrieval of episodic memory.iScience · 2025Article
- Hippocampal-prefrontal orchestration supports higher-order learning for creative ideation.Nature communications · 2025Article
- Hippocampal functional connectivity changes associated with active and lecture-based physics learning.bioRxiv : the preprint server for biology · 2025Article
- Crossmodal semantic congruence and rarity improve episodic memory.Memory & cognition · 2025Article
- Differentiation of Related Events in Hippocampus Supports Memory Reinstatement in Development.Journal of cognitive neuroscience · 2025Article
- Unexpected Twists: Electrophysiological Correlates of Encoding and Retrieval of Events Eliciting Prediction Error.Psychophysiology · 2025Article
- Predictions enable top-down pattern separation in the macaque face-processing hierarchy.Nature communications · 2024Article
- Semantic associations restore neural encoding mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Dissimilarities of neural representations of extinction trials are associated with extinction learning performance and renewal level.Frontiers in behavioral neuroscience · 2024Article
- Neural Mechanisms of Learning and Consolidation of Morphologically Derived Words in a Novel Language: Evidence From Hebrew Speakers.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Predictions transform memories: How expected versus unexpected events are integrated or separated in memory.Neuroscience and biobehavioral reviews · 2023Review
- Evolution of Human Brain Left-Right Asymmetry: Old Genes with New Functions.Molecular biology and evolution · 2023Article
- Intersubject similarity in neural representations underlies shared episodic memory content.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Effects of prior knowledge on brain activation and functional connectivity during memory retrieval.Scientific reports · 2023Article
- Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An adaptive memory system rarely learns information tabula rasa, but rather builds on prior knowledge to facilitate learning. How prior knowledge influences the neural representation of novel associations remains unknown. Here, participants associated pairs of faces in two conditions: a famous, highly familiar face with a novel face or two novel faces while undergoing fMRI. We examine multivoxel activity patterns corresponding to individual faces before and after learning. The activity patterns representing members of famous-novel pairs becomes separated in the hippocampus, that is, more distinct from one another through learning, in striking contrast to paired novel faces that become similar. In the left inferior frontal gyrus, however, prior knowledge leads to integration, and in a specific direction: the representation of the novel face becomes similar to that of the famous face after learning, suggesting assimilation of new into old memories. We propose that hippocampal separation might resolve interference between existing and newly learned information, allowing cortical assimilation. Thus, associative learning with versus without prior knowledge relies on radically different computations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.