ArticleMedical science monitor : international medical journal of experimental and clinical research2020
Cluster Analysis of the Associations among Physical Frailty, Cognitive Impairment and Mental Disorders.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Factors influencing subjective well-being in individuals with functional dyspepsia - a path analysis of sex and psychological factors.Frontiers in medicine · 2026Article
- Frailty and Cognitive Decline in Hospitalized Elderly Patients: Associations with Clinical and Laboratory Parameters.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Independent and combined associations of depression and cognitive impairment with frailty in oldest-old adults.BMC psychology · 2024Article
- Psycho-social and health predictors of loneliness in older primary care patients and mediating mechanisms linking comorbidities and loneliness.BMC geriatrics · 2023Article
- Latent Subtype of Cognitive Frailty among Multimorbidity Older Adults and Their Association with Social Relationships.Healthcare (Basel, Switzerland) · 2023Article
- Cross-Talk between the Cytokine IL-37 and Thyroid Hormones in Modulating Chronic Inflammation Associated with Target Organ Damage in Age-Related Metabolic and Vascular Conditions.International journal of molecular sciences · 2022Review
- Health Care Utilization and Out-of-Pocket Payments among Elderly with Cognitive Frailty in Malaysia.International journal of environmental research and public health · 2022Article
- Social support and subsequent cognitive frailty during a 1-year follow-up of older people: the mediating role of psychological distress.BMC geriatrics · 2022Article
- Patterns of the physical, cognitive, and mental health status of older individuals in a real-life primary care setting and differences in coping styles.Frontiers in medicine · 2022Article
- Different Anesthetic Drugs Mediate Changes in Neuroplasticity During Cognitive Impairment in Sleep-Deprived Rats via Different Factors.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Low Psychological Resilience in Older Individuals: An Association with Increased Inflammation, Oxidative Stress and the Presence of Chronic Medical Conditions.International journal of molecular sciences · 2021Review
- Clusters of Physical Frailty and Cognitive Impairment and Their Associated Comorbidities in Older Primary Care Patients.Healthcare (Basel, Switzerland) · 2021Article
- Cardiovascular risk and aging: the need for a more comprehensive understanding.Journal of geriatric cardiology : JGC · 2021Article
- Frailty and HIV: Moving from Characterization to Intervention.Current HIV/AIDS reports · 2021Review
- AI and Big Data in Healthcare: Towards a More Comprehensive Research Framework for Multimorbidity.Journal of clinical medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Physical frailty, cognitive impairment, and symptoms of anxiety and depression frequently co-occur in later life, but, to date, each has been assessed separately. The present study assessed their patterns in primary care patients aged ≥60 years. MATERIAL AND METHODS This cross-sectional study evaluated 263 primary care patients aged ≥60 years in eastern Croatia in 2018. Physical frailty, cognitive impairment, anxiety and depression, were assessed using the Fried phenotypic model, the Mini-Mental State Examination (MMSE), the Geriatric Anxiety Scale (GAS), and the Geriatric Depression Scale (GDS), respectively. Patterns were identified by latent class analysis (LCA), Subjects were assorted by age, level of education, and domains of psychological and cognitive tests to determine clusters. RESULTS Subjects were assorted into four clusters: one cluster of relatively healthy individuals (61.22%), and three pathological clusters, consisting of subjects with mild cognitive impairment (23.95%), cognitive frailty (7.98%), and physical frailty (6.85%). A multivariate, multinomial logistic regression model found that the main determinants of the pathological clusters were increasing age and lower mnestic functions. Lower performance on mnestic tasks was found to significantly determine inclusion in the three pathological clusters. The non-mnestic function, attention, was specifically associated with cognitive impairment, whereas psychological symptoms of anxiety and dysphoria were associated with physical frailty. CONCLUSIONS Clustering of physical and cognitive performances, based on combinations of their grades of severity, may be superior to modelling of their respective entities, including the continuity and non-linearity of age-related accumulation of pathologic conditions.
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Registered trials
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