Evidence map›Paper›PMID 32928967›Full record

ArticleNeurology2020

Association between

Jin San Lee, Hyejoo Lee, Seongbeom Park, Yeongsim Choe, Yu Hyun Park, Bo Kyoung Cheon, Alice Hahn, Rik Ossenkoppele, Hee Jin Kim, Seonwoo Kim and 11 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 1 institution in 1 country.

Jin San LeeFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA. sangwonseo@empal.com hyejoo271@gmail.com.
Hyejoo LeeFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA. sangwonseo@empal.com hyejoo271@gmail.com.
Seongbeom ParkFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Yeongsim ChoeFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Yu Hyun ParkFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Bo Kyoung CheonFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Alice HahnFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Rik OssenkoppeleFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Hee Jin KimFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Seonwoo KimFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Heejin YooFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Hyemin JangFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Soo Hyun ChoFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.ORCID 0000-0002-4262-1468
Seung Joo KimFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Jun Pyo KimFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Young Hee JungFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Key-Chung ParkFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Charles DeCarliFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Michael W WeinerFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Duk L NaFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA.
Sang Won SeoFrom the Department of Neurology (J.S.L., H.L., S.P., Y.C., Y.H.P., B.K.C., A.H., H.J.K., H.J., J.P.K., D.L.N., S.W.S.), Samsung Alzheimer Research Center (H.J.K., H.J., J.P.K., D.L.N., S.W.S.), and Statistics and Data Center (S.K., H.Y.), Samsung Medical Center; Department of Intelligent Precision Healthcare Convergence (S.W.S.), Sungkyunkwan University School of Medicine; Department of Health Sciences and Technology (S.W.S.), SAIHST, Sungkyunkwan University; Department of Neurology (J.S.L., K.-C.P.), Kyung Hee University College of Medicine, Kyung Hee University Hospital, Seoul, Korea; Department of Neurology and Alzheimer Center (R.O.), Neuroscience Campus Amsterdam, VU University Medical Center, the Netherlands; Department of Neurology (S.H.C.), Chonnam National University Medical School, Gwangju; Department of Neurology (S.J.K.), Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon; Department of Neurology (Y.H.J.), Myungji Hospital, Goyang, Korea; Department of Neurology and Center for Neuroscience (C.D.), University of California, Davis; Department of Medicine (M.W.W.), University of California; and Department of Veterans Affairs Medical Center (M.W.W.), Center for Imaging of Neurodegenerative Diseases, San Francisco, CA. sangwonseo@empal.com hyejoo271@gmail.com.
Norwegian Womens Public Health Association · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the association between

methodsThis was a cross-sectional study of 310 patients with SVCI and 999 with ADCI. To evaluate the effects of

resultsIn comparison with ε3 homozygotes, in the ADCI group, ε2 carriers showed a lower frequency of Aβ positivity (odds ratio [OR] 0.43, 95% confidence interval [CI] 0.23-0.79), while in the SVCI group, ε2 carriers showed a higher frequency of Aβ positivity (OR 2.26, 95% CI 1.02-5.01). In particular, we observed an interaction effect of ε2 carrier status and diagnostic group on Aβ positivity (OR 5.12, 95% CI 1.93-13.56), in that relative to ε3 homozygotes, there were more Aβ-positive ε2 carriers in the SVCI group than in the ADCI group. We also identified latent subgroups of Aβ-positive

conclusionsOur findings suggest that

Indexed as

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesApolipoprotein E2Body BurdenCognitive DysfunctionCross-Sectional StudiesDementia, VascularFemaleGenetic Predisposition to DiseaseGenotypeHeterozygoteHumansMagnetic Resonance ImagingMaleAmyloid beta-PeptidesApolipoprotein E2

Identifiers

PMID32928967
PMCPMC7682916
OpenAlexW3086678889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.