ArticleDevelopment (Cambridge, England)2020
Establishment of a relationship between blastomere geometry and YAP localisation during compaction.
Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Unified Transcriptome and Mechanics Map of the Intact Mammalian Preimplantation Embryo In Situ.bioRxiv : the preprint server for biology · 2026Article
- Generative model for the first cell fate bifurcation in mammalian development.Development (Cambridge, England) · 2025Article
- Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development.Developmental biology · 2025Article
- Geometric, cell cycle and maternal-to-zygotic transition-associated YAP dynamics during preimplantation embryo development.bioRxiv : the preprint server for biology · 2025Article
- Regulation of organelle size and organization during development.Seminars in cell & developmental biology · 2023Review
- Mechanical regulation of chromatin and transcription.Nature reviews. Genetics · 2022Review
- Epithelial dynamics during early mouse development.Current opinion in genetics & development · 2022Review
- Regionally specific levels and patterns of keratin 8 expression in the mouse embryo visceral endoderm emerge upon anterior-posterior axis determination.Frontiers in cell and developmental biology · 2022Article
- Emerging Role of Mechanical Forces in Cell Fate Acquisition.Frontiers in cell and developmental biology · 2022Review
- Sculpting with stem cells: how models of embryo development take shape.Development (Cambridge, England) · 2021Article
- Review
- IVEN: A quantitative tool to describe 3D cell position and neighbourhood reveals architectural changes in FGF4-treated preimplantation embryos.PLoS biology · 2021Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Precise patterning within the three-dimensional context of tissues, organs and embryos implies that cells can sense their relative position. During preimplantation development, outside and inside cells rely on apicobasal polarity and the Hippo pathway to choose their fate. Despite recent findings suggesting that mechanosensing might be central to this process, the relationship between blastomere geometry (i.e. shape and position) and the Hippo pathway effector YAP remains unknown. We used a highly quantitative approach to analyse information on the geometry and YAP localisation of individual blastomeres of mouse and human embryos. We identified the proportion of exposed cell surface area as most closely correlating with the nuclear localisation of YAP. To test this relationship, we developed several hydrogel-based approaches to alter blastomere geometry in cultured embryos. Unbiased clustering analyses of blastomeres from such embryos revealed that this relationship emerged during compaction. Our results therefore pinpoint the time during early embryogenesis when cells acquire the ability to sense changes in geometry and provide a new framework for how cells might integrate signals from different membrane domains to assess their relative position within the embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.